Skip to main content

Advertisement

SpringerLink
Log in

Endometrial Hyperplasia: A Clinicopathological Study in a Tertiary Care Hospital

  • Original Article
  • Published:
The Journal of Obstetrics and Gynecology of India Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Objective

To evaluate the clinical as well as histomorphologic features in different cases of endometrial hyperplasia along with its relative occurrence.

Materials and Methods

A one-and-a-half-year prospective study was conducted on histopathologically diagnosed cases of endometrial hyperplasia in a tertiary care hospital. Apart from relevant clinical findings, histomorphologic details were noted and statistically analyzed.

Observations

Maximum number (46.5 %) of endometrial hyperplasia occurred in patients of 41–50 years age group. Majority (55.2 %) of the patients were found to be premenopausal. Menorrhagia was the most common (49.6 %) clinical presentation followed by postmenopausal bleeding (30.8 %). Simple hyperplasia without atypia was the most common type (95.6 %) followed by complex hyperplasia without atypia (3.6 %) and complex hyperplasia with atypia (0.8 %), respectively. The study of gland–stroma ratio revealed 65:35 to be the most frequent (34 %) ratio; variable-sized glands with cystic dilatation (60.4 %) was the commonest gland architecture and most of the cases (99.2 %) showed the absence of atypia. Associated histopathological findings included a case each of endometrial adenocarcinoma and undifferentiated endometrial stromal sarcoma along with the common leiomyoma and progesterone effects.

Conclusion

Menorrhagia was the most common presenting complaint in cases of endometrial hyperplasia. The cases were mostly in the premenopausal age group. Simple endometrial hyperplasia without atypia was the commonest type diagnosed histopathologically. Histopathological examination along with clinical details is essential to give the final opinion regarding the diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Speroff L, Fritz MA. Dysfunctional uterine bleeding. In: Speroff L, Fritz MA, editors. Clinical gynecologic endocrinology & infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 547–72.

    Google Scholar 

  2. O’Dowd MJ, Philipp EE. Cancer of the uterus. The history of obstetrics and gynaecology. 1st ed. New York: Parthenon Publishing Group; 1994. p. 571–80.

    Google Scholar 

  3. Mutter GL. Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group. Gynecol Oncol. 2000;76:287–90.

    Article  CAS  PubMed  Google Scholar 

  4. Rao S, Sundaram S, Narasimhan R. Biological behavior of preneoplastic conditions of the endometrium: a retrospective 16-year study in south India. Indian J Med Paediatr Oncol. 2009;30:131–5.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Silverberg SG, Kurman RJ, Nogales F, et al. Tumours of uterine corpus. In: Tavassoli FA, Devilee P, editors. World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC Press; 2003. p. 217–57.

    Google Scholar 

  6. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer. 1985;56:403–12.

    Article  CAS  PubMed  Google Scholar 

  7. Muzaffar M, Akhtar KA, Yasmin S, et al. Menstrual irregularities with excessive blood loss: a clinico-pathological correlation. J Pak Med Assoc. 2005;55:486–9.

    PubMed  Google Scholar 

  8. Takreem A, Danish N, Razaq S. Incidence of endometrial hyperplasia in 100 cases presenting with polymenorrhagia/menorrhagia in perimenupausal women. J Ayub Med Coll Abbottabad. 2009;21:60–3.

    PubMed  Google Scholar 

  9. Lacey JV Jr, Ioffe OB, Ronnett BM, et al. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer. 2008;98:45–53.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Chamlian DL, Taylor HB. Endometrial hyperplasia in young women. Obstet Gynecol. 1970;36:659–66.

    CAS  PubMed  Google Scholar 

  11. Horn LC, Schnurrbusch U, Bilek K, et al. Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment. Int J Gynecol Cancer. 2004;14:348–53.

    Article  PubMed  Google Scholar 

  12. Kistner RW. Histological effects of progestins on hyperplasia and carcinoma in situ of the endometrium. Cancer. 1959;12:1106–22.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, India

    Gargi Raychaudhuri (Assistant Professor) & Sajeeb Mondal (Assistant Professor)

  2. Sarsuna Satellite Township, Phase – I, House No. H-1/20, Biren Roy Road (West), Kolkata, 700061, India

    Gargi Raychaudhuri (Assistant Professor)

  3. Department of Pathology, Murshidabad Medical College and Hospital, Berhampore, India

    Anjali Bandyopadhyay (Professor)

  4. Department of Gynecology and Obstetrics, Institute of Post Graduate Medical Education and Research, Kolkata, India

    Dipnarayan Sarkar (Assistant Professor) & Sarbeswar Mandal (Assistant Professor)

  5. Institute of Post Graduate Medical Education and Research, Kolkata, India

    Pradip Kumar Mitra (Professor, Director)

Authors
  1. Gargi Raychaudhuri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anjali Bandyopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dipnarayan Sarkar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sarbeswar Mandal
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sajeeb Mondal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Pradip Kumar Mitra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gargi Raychaudhuri.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raychaudhuri, G., Bandyopadhyay, A., Sarkar, D. et al. Endometrial Hyperplasia: A Clinicopathological Study in a Tertiary Care Hospital. J Obstet Gynecol India 63, 394–398 (2013). https://doi.org/10.1007/s13224-013-0414-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13224-013-0414-2

Keywords

Search

Navigation