Abstract
Due to the lack of early diagnosis, cancer remains as one of the leading cause of human mortality. Inability to translate research into clinical trials and also inability of chemotherapeutics delivery to targeted tumor sites are major drawbacks in cancer therapeutics. With the emergence of nanomedicine, several nanoprobes (conjugated with targeting ligands and chemotherapeutic drugs) are developed. It can interact with biological system and thus sense and monitor the biological events with high efficiency and accuracy along with therapy application. Nanoparticles like gold and iron oxide are frequently used in the computed tomography and magnetic resonance imaging applications, respectively. Moreover, enzymatic activity of gold and iron oxide nanoparticles enables the visible colorimetric diagnostic of cancer cells, whereas, fluorescence property of quantum dots and upconversion nanoparticles helps in in vivo imaging application. Other than this, drug conjugation with nanoparticles also reduces the systemic toxic effect of chemotherapeutic drugs. Due to their several unique intrinsic properties, nanoparticles itself can also be employed as therapeutics in cancer treatment by photothermal therapy (PTT) and photodynamic therapy (PDT). Thus, the main focus of this review is to emphasize on current progress in diagnostic and therapeutic application of nanoprobes in cancer.
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AbdElhamid AS, Zayed DG, Helmy MW, Ebrahim SM, Bahey-El-Din M, Zein-El-Dein EA, El-Gizawy SA, Elzoghby AO (2018) Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor/herbal therapy of breast cancer. Nanomedicine (Lond) 13(20):2637–2656. https://doi.org/10.2217/nnm-2018-0196
Akram M, Iqbal M, Daniyal M, Khan AU (2017) Awareness and current knowledge of breast cancer. Biol Res 50(1):33. https://doi.org/10.1186/s40659-017-0140-9
Amer MH (2014) Gene therapy for cancer: present status and future perspective. Mol Cell Ther 2:27. https://doi.org/10.1186/2052-8426-2-27
Audi G, Bersillon O, Blachot J, Wapstra A (2003) The NUBASE evaluation of nuclear and decay properties. Nuclear Phys A 729(1):3–128
Bansal S, Singh J, Kumari U, Kaur IP, Barnwal RP, Kumar R, Singh S, Singh G, Chatterjee M (2019) Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer. Int J Nanomed 14:809–818. https://doi.org/10.2147/IJN.S188552
Barlas FB, Aydindogan E, Arslan M, Timur S, Yagci Y (2019) Gold nanoparticle conjugated poly(p-phenylene-β-cyclodextrin)-graft-poly(ethylene glycol) for theranostic applications. J Appl Polym Sci 136(12):47250. https://doi.org/10.1002/app.47250
Bi H, He F, Dai Y, Xu J, Dong Y, Yang D, Gai S, Li L, Li C, Yang P (2018) Quad-model imaging-guided high-efficiency phototherapy based on upconversion nanoparticles and ZnFe2O4 Integrated graphene oxide. Inorg Chem 57(16):9988–9998. https://doi.org/10.1021/acs.inorgchem.8b01159
Bray F, Jemal A, Grey N, Ferlay J, Forman D (2012) Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol 13(8):790–801. https://doi.org/10.1016/S1470-2045(12)70211-5
Cai Q, Xu J, Yang D, Dai Y, Yang G, Zhong C, Gai S, He F, Yang P (2018) Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy. J Mater Chem B 6(48):8148–8162. https://doi.org/10.1039/C8TB02407C
Cao Y, Dong H, Yang Z, Zhong X, Chen Y, Dai W, Zhang X (2017) Aptamer-conjugated graphene quantum dots/porphyrin derivative theranostic agent for intracellular cancer-related microRNA detection and fluorescence-guided photothermal/photodynamic synergetic therapy. ACS Appl Mater Interfaces 9(1):159–166. https://doi.org/10.1021/acsami.6b13150
Casalini P, Iorio MV, Galmozzi E, Menard S (2004) Role of HER receptors family in development and differentiation. J Cell Physiol 200(3):343–350. https://doi.org/10.1002/jcp.20007
Chan MS, Tam DY, Dai Z, Liu LS, Ho JW, Chan ML, Xu D, Wong MS, Tin C, Lo PK (2016) Mitochondrial delivery of therapeutic agents by amphiphilic DNA nanocarriers. Small 12(6):770–781. https://doi.org/10.1002/smll.201503051
Chang C-H, Tsai IC, Chiang C-J, Chao Y-P (2019a) A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide. J Taiwan Inst Chem Eng 97:88–95. https://doi.org/10.1016/j.jtice.2019.02.013
Chang J, Zhang A, Huang Z, Chen Y, Zhang Q, Cui D (2019b) Monodisperse Au@Ag core-shell nanoprobes with ultrasensitive SERS-activity for rapid identification and Raman imaging of living cancer cells. Talanta 198:45–54. https://doi.org/10.1016/j.talanta.2019.01.085
Chaudhary A, Dwivedi C, Gupta A, Nandi CK (2015) One pot synthesis of doxorubicin loaded gold nanoparticles for sustained drug release. RSC Adv 5(118):97330–97334. https://doi.org/10.1039/C5RA12892G
Chen H, Zhen Z, Todd T, Chu PK, Xie J (2013) Nanoparticles for improving cancer diagnosis. Mater Sci Eng R Rep 74(3):35–69. https://doi.org/10.1016/j.mser.2013.03.001
Chen G, Qiu H, Prasad PN, Chen X (2014) Upconversion nanoparticles: design, nanochemistry, and applications in theranostics. Chem Rev 114(10):5161–5214. https://doi.org/10.1021/cr400425h
Chen C, Zhou S, Cai Y, Tang F (2017a) Nucleic acid aptamer application in diagnosis and therapy of colorectal cancer based on cell-SELEX technology. NPJ Precis Oncol 1(1):37. https://doi.org/10.1038/s41698-017-0041-y
Chen F, Gao W, Qiu X, Zhang H, Liu L, Liao P, Fu W, Luo Y (2017b) Graphene quantum dots in biomedical applications: recent advances and future challenges. Front Lab Med 1(4):192–199. https://doi.org/10.1016/j.flm.2017.12.006
Chen J, Li X, Zhao X, Wu Q, Zhu H, Mao Z, Gao C (2018) Doxorubicin-conjugated pH-responsive gold nanorods for combined photothermal therapy and chemotherapy of cancer. Bioact Mater 3(3):347–354. https://doi.org/10.1016/j.bioactmat.2018.05.003
Chen X, Han W, Zhao X, Tang W, Wang F (2019) Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release. Sci Rep 9(1):6754. https://doi.org/10.1038/s41598-019-43106-9
Cheng Y, Cheng H, Jiang C, Qiu X, Wang K, Huan W, Yuan A, Wu J, Hu Y (2015) Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat Commun 6:8785. https://doi.org/10.1038/ncomms9785
Cheung A, Bax HJ, Josephs DH, Ilieva KM, Pellizzari G, Opzoomer J, Bloomfield J, Fittall M, Grigoriadis A, Figini M, Canevari S, Spicer JF, Tutt AN, Karagiannis SN (2016) Targeting folate receptor alpha for cancer treatment. Oncotarget 7(32):52553–52574. https://doi.org/10.18632/oncotarget.9651
Chung US, Kim JH, Kim B, Kim E, Jang WD, Koh WG (2016) Dendrimer porphyrin-coated gold nanoshells for the synergistic combination of photodynamic and photothermal therapy. Chem Commun (Camb) 52(6):1258–1261. https://doi.org/10.1039/c5cc09149g
Cryer AM, Thorley AJ (2019) Nanotechnology in the diagnosis and treatment of lung cancer. Pharmacol Ther 198:189–205. https://doi.org/10.1016/j.pharmthera.2019.02.010
De M, Ghosh S, Sen T, Shadab M, Banerjee I, Basu S, Ali N (2018) A novel therapeutic strategy for cancer using phosphatidylserine targeting stearylamine-bearing cationic liposomes. Mol Ther Nucleic Acids 10:9–27. https://doi.org/10.1016/j.omtn.2017.10.019
Dean L (2015) Trastuzumab (herceptin) therapy and ERBB2 (HER2) genotype. In: Medical Genetics Summaries [Internet]. National Center for Biotechnology Information (US)
Deng H, Dai F, Ma G, Zhang X (2015) Theranostic gold nanomicelles made from biocompatible comb-like polymers for thermochemotherapy and multifunctional imaging with rapid clearance. Adv Mater 27(24):3645–3653. https://doi.org/10.1002/adma.201501420
Dey C, Ghosh A, Ahir M, Ghosh A, Goswami MM (2018) Improvement of anticancer drug release by cobalt ferrite magnetic nanoparticles through combined ph and temperature responsive technique. ChemPhysChem 19(21):2872–2878. https://doi.org/10.1002/cphc.201800535
Diamantis N, Banerji U (2016) Antibody-drug conjugates–an emerging class of cancer treatment. Br J Cancer 114(4):362–367. https://doi.org/10.1038/bjc.2015.435
Dong H, Sun LD, Yan CH (2015) Energy transfer in lanthanide upconversion studies for extended optical applications. Chem Soc Rev 44(6):1608–1634. https://doi.org/10.1039/c4cs00188e
Du AW, Stenzel MH (2014) Drug carriers for the delivery of therapeutic peptides. Biomacromol 15(4):1097–1114. https://doi.org/10.1021/bm500169p
Elbialy NS, Fathy MM, Al-Wafi R, Darwesh R, Abdel-Dayem UA, Aldhahri M, Noorwali A, Al-Ghamdi AA (2019) Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy. Int J Pharm 554:256–263. https://doi.org/10.1016/j.ijpharm.2018.11.021
Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I (2016) Cytochrome c as a potentially clinical useful marker of mitochondrial and cellular damage. Front Immunol 7:279. https://doi.org/10.3389/fimmu.2016.00279
Fang M, Dai-Wen Li PY (2016) Quantum dots for cancer diagnosis. Biomed Nanomater. https://doi.org/10.1002/9783527694396.ch8
Farooq MU, Novosad V, Rozhkova EA, Wali H, Ali A, Fateh AA, Neogi PB, Neogi A, Wang Z (2018) Gold nanoparticles-enabled efficient dual delivery of anticancer therapeutics to HeLa cells. Sci Rep 8(1):2907. https://doi.org/10.1038/s41598-018-21331-y
Feng T, Ai X, An G, Yang P, Zhao Y (2016) Charge-convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency. ACS Nano 10(4):4410–4420. https://doi.org/10.1021/acsnano.6b00043
Feng J, Huang P, Shi S, Deng KY, Wu FY (2017) Colorimetric detection of glutathione in cells based on peroxidase-like activity of gold nanoclusters: a promising powerful tool for identifying cancer cells. Anal Chim Acta 967:64–69. https://doi.org/10.1016/j.aca.2017.02.025
Fernandes AR, Jesus J, Martins P, Figueiredo S, Rosa D, Martins LM, Corvo ML, Carvalheiro MC, Costa PM, Baptista PV (2017) Multifunctional gold-nanoparticles: a nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. J Control Release 245:52–61. https://doi.org/10.1016/j.jconrel.2016.11.021
Ferrara N (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2(10):795–803. https://doi.org/10.1038/nrc909
Fu S, Wang S, Zhang X, Qi A, Liu Z, Yu X, Chen C, Li L (2017) Structural effect of Fe3O4 nanoparticles on peroxidase-like activity for cancer therapy. Colloids Surf B Biointerfaces 154:239–245. https://doi.org/10.1016/j.colsurfb.2017.03.038
Fukaminato T, Ishida S, Métivier R (2018) Photochromic fluorophores at the molecular and nanoparticle levels: fundamentals and applications of diarylethenes. NPG Asia Mater 10(9):859–881. https://doi.org/10.1038/s41427-018-0075-9
Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman W, Chintharlapalli S, Abada P, Sherman M, Zhu AX (2019) Biology and significance of alpha-fetoprotein in hepatocellular carcinoma. Liver Int. https://doi.org/10.1111/liv.14223
Gao C, Deng ZJ, Peng D, Jin YS, Ma Y, Li YY, Zhu YK, Xi JZ, Tian J, Dai ZF, Li CH, Liang XL (2016) Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging. Cancer Biol Med 13(3):349–359. https://doi.org/10.20892/j.issn.2095-3941.2016.0048
Gardner A, Ruffell B (2016) Dendritic cells and cancer immunity. Trends Immunol 37(12):855–865. https://doi.org/10.1016/j.it.2016.09.006
Ge J, Jia Q, Liu W, Guo L, Liu Q, Lan M, Zhang H, Meng X, Wang P (2015) Red-emissive carbon dots for fluorescent, photoacoustic, and thermal theranostics in living mice. Adv Mater 27(28):4169–4177. https://doi.org/10.1002/adma.201500323
Gellerman G, Baskin S, Galia L, Gilad Y, Firer MA (2013) Drug resistance to chlorambucil in murine B-cell leukemic cells is overcome by its conjugation to a targeting peptide. Anticancer Drugs 24(2):112–119. https://doi.org/10.1097/CAD.0b013e32835bb17a
Gong P, Sun L, Wang F, Liu X, Yan Z, Wang M, Zhang L, Tian Z, Liu Z, You J (2019) Highly fluorescent N-doped carbon dots with two-photon emission for ultrasensitive detection of tumor marker and visual monitor anticancer drug loading and delivery. Chem Eng J 356:994–1002. https://doi.org/10.1016/j.cej.2018.09.100
Greish K (2010) Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. Methods Mol Biol 624:25–37. https://doi.org/10.1007/978-1-60761-609-2_3
Guo J, Rahme K, He Y, Li LL, Holmes JD, O’Driscoll CM (2017) Gold nanoparticles enlighten the future of cancer theranostics. Int J Nanomed 12:6131–6152. https://doi.org/10.2147/IJN.S140772
Guryev EL, Volodina NO, Shilyagina NY, Gudkov SV, Balalaeva IV, Volovetskiy AB, Lyubeshkin AV, Sen AV, Ermilov SA, Vodeneev VA, Petrov RV, Zvyagin AV, Alferov ZI, Deyev SM (2018) Radioactive ((90)Y) upconversion nanoparticles conjugated with recombinant targeted toxin for synergistic nanotheranostics of cancer. Proc Natl Acad Sci USA 115(39):9690–9695. https://doi.org/10.1073/pnas.1809258115
Hale SJM, Perrins RD, Garci AC, Pace A, Peral U, Patel KR, Robinson A, Williams P, Ding Y, Saito G, Rodriguez MA, Perera I, Barrientos A, Conlon K, Damment S, Porter J, Coulter T (2019) DM1 loaded ultrasmall gold nanoparticles display significant efficacy and improved tolerability in murine models of hepatocellular carcinoma. Bioconjugate Chem 30(3):703–713. https://doi.org/10.1021/acs.bioconjchem.8b00873
Han Y, An Y, Jia G, Wang X, He C, Ding Y, Tang Q (2018) Theranostic micelles based on upconversion nanoparticles for dual-modality imaging and photodynamic therapy in hepatocellular carcinoma. Nanoscale 10(14):6511–6523. https://doi.org/10.1039/C7NR09717D
He J, Dong J, Hu Y, Li G, Hu Y (2019) Design of Raman tag-bridged core-shell Au@Cu3(BTC)2 nanoparticles for Raman imaging and synergistic chemo-photothermal therapy. Nanoscale 11(13):6089–6100. https://doi.org/10.1039/c9nr00041k
Herreros-Villanueva M, Bujanda L (2016) Glypican-1 in exosomes as biomarker for early detection of pancreatic cancer. Ann Transl Med 4(4):64. https://doi.org/10.3978/j.issn.2305-5839.2015.10.39
Hlapisi N, Motaung TE, Linganiso LZ, Oluwafemi OS, Songca SP (2019) Encapsulation of gold nanorods with porphyrins for the potential treatment of cancer and bacterial diseases: a critical review. Bioinorg Chem Appl 2019:7147128. https://doi.org/10.1155/2019/7147128
Ho CM, Chang SF, Hsiao CC, Chien TY, Shih DTB (2012) Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma. J Biomed Sci. https://doi.org/10.1186/1423-0127-19-23
Hu D, Sheng Z, Fang S, Wang Y, Gao D, Zhang P, Gong P, Ma Y, Cai L (2014) Folate receptor-targeting gold nanoclusters as fluorescence enzyme mimetic nanoprobes for tumor molecular colocalization diagnosis. Theranostics 4(2):142–153. https://doi.org/10.7150/thno.7266
Hu J, Liu MH, Li Y, Tang B, Zhang CY (2018) Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level. Chem Sci 9(3):712–720. https://doi.org/10.1039/c7sc04296e
Huang P, Lin J, Wang X, Wang Z, Zhang C, He M, Wang K, Chen F, Li Z, Shen G, Cui D, Chen X (2012) Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy. Adv Mater 24(37):5104–5110. https://doi.org/10.1002/adma.201200650
Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6):673–687
Imanparast A, Bakhshizadeh M, Salek R, Sazgarnia A (2018) Pegylated hollow gold-mitoxantrone nanoparticles combining photodynamic therapy and chemotherapy of cancer cells. Photodiagn Photodyn Ther 23:295–305. https://doi.org/10.1016/j.pdpdt.2018.07.011
Israeli RS, Powell CT, Fair WR, Heston WD (1993) Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res 53(2):227–230
Jie G, Gao X, Ge J, Li C (2019) Multifunctional DNA nanocage with CdTe quantum dots for fluorescence detection of human 8-oxoG DNA glycosylase 1 and doxorubicin delivery to cancer cells. Mikrochim Acta 186(2):85. https://doi.org/10.1007/s00604-018-3199-2
Kale SS, Burga RA, Sweeney EE, Zun Z, Sze RW, Tuesca A, Subramony JA, Fernandes R (2017) Composite iron oxide-Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors. Int J Nanomed 12:6413–6424. https://doi.org/10.2147/IJN.S144515
Kalimuthu K, Lubin BC, Bazylevich A, Gellerman G, Shpilberg O, Luboshits G, Firer MA (2018) Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. J Nanobiotechnol 16(1):34. https://doi.org/10.1186/s12951-018-0362-1
Key J, Cooper C, Kim AY, Dhawan D, Knapp DW, Kim K, Park JH, Choi K, Kwon IC, Park K, Leary JF (2012) In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles. J Control Release 163(2):249–255. https://doi.org/10.1016/j.jconrel.2012.07.038
Khan SN, Lal SK, Kumar P, Khan AU (2010) Effect of mitoxantrone on proliferation dynamics and cell-cycle progression. Biosci Rep 30(6):375–381. https://doi.org/10.1042/BSR20090119
Kim Y, Lee S, Kim D, Noh K, Oh KS, Cho S, Choi E, Kim K-p, Huh KM (2018) Preparation and characterization of poly (ethylene glycol)-doxorubicin/SPION magnetic nanoparticles for cancer therapy. POLYMER-KOREA 42(6):1059–1067
Kim JS, Jang JY, Cheon HJ, Cho S, Jang IS, Yu BJ, Kim MI (2019) Co(3)O(4)/Au hybrid nanostructures as efficient peroxidase mimics for colorimetric biosensing. J Nanosci Nanotechnol 19(10):6696–6702. https://doi.org/10.1166/jnn.2019.17098
Ko NR, Hong SH, Nafiujjaman M, An SY, Revuri V, Lee SJ, Kwon IK, Lee Y-k, Oh SJ (2019) Glutathione-responsive PEGylated GQD-based nanomaterials for diagnosis and treatment of breast cancer. J Ind Eng Chem 71:301–307. https://doi.org/10.1016/j.jiec.2018.11.039
Kobayashi M, Sawada K, Kimura T (2017) Potential of integrin inhibitors for treating ovarian cancer: a literature review. Cancers (Basel). https://doi.org/10.3390/cancers9070083
Kou J, Dou D, Yang L (2017) Porphyrin photosensitizers in photodynamic therapy and its applications. Oncotarget 8(46):81591–81603. https://doi.org/10.18632/oncotarget.20189
Lai X, Zhao H, Zhang Y, Guo K, Xu Y, Chen S, Zhang J (2018) Intranasal delivery of copper oxide nanoparticles induces pulmonary toxicity and fibrosis in C57BL/6 mice. Sci Rep 8(1):4499. https://doi.org/10.1038/s41598-018-22556-7
Lee H, Lee JH, Kim J, Mun JH, Chung J, Koo H, Kim C, Yun SH, Hahn SK (2016) Hyaluronate-gold nanorod/DR5 antibody complex for noninvasive theranosis of skin cancer. ACS Appl Mater Interfaces 8(47):32202–32210. https://doi.org/10.1021/acsami.6b11319
Lee S, Lee C, Park S, Lim K, Kim SS, Kim JO, Lee ES, Oh KT, Choi HG, Youn YS (2018) Facile fabrication of highly photothermal-effective albumin-assisted gold nanoclusters for treating breast cancer. Int J Pharm 553(1–2):363–374. https://doi.org/10.1016/j.ijpharm.2018.10.063
Li P, Yan Y, Chen B, Zhang P, Wang S, Zhou J, Fan H, Wang Y, Huang X (2018a) Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy. Biomater Sci 6(4):877–884. https://doi.org/10.1039/c7bm01113j
Li Q, Li X, Zhang L, Zuo J, Zhang Y, Liu X, Tu L, Xue B, Chang Y, Kong X (2018b) An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy. Nanoscale 10(26):12356–12363. https://doi.org/10.1039/c8nr00446c
Li K, Hong E, Wang B, Wang Z, Zhang L, Hu R, Wang B (2019a) Advances in the application of upconversion nanoparticles for detecting and treating cancers. Photodiagn Photodyn Ther 25:177–192. https://doi.org/10.1016/j.pdpdt.2018.12.007
Li W, Xue B, Shi K, Qu Y, Chu B, Qian Z (2019b) Magnetic iron oxide nanoparticles/10-hydroxy camptothecin co-loaded nanogel for enhanced photothermal-chemo therapy. Appl Mater Today 14:84–95. https://doi.org/10.1016/j.apmt.2018.11.008
Liu J, Yu M, Zhou C, Yang S, Ning X, Zheng J (2013) Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance. J Am Chem Soc 135(13):4978–4981. https://doi.org/10.1021/ja401612x
Liu Y, Ma D, Ji C (2015) Zinc fingers and homeoboxes family in human diseases. Cancer Gene Ther 22(5):223–226. https://doi.org/10.1038/cgt.2015.16
Liu H, Zhang J, Chen X, Du XS, Zhang JL, Liu G, Zhang WG (2016a) Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside. Nanoscale 8(15):7808–7826. https://doi.org/10.1039/c6nr00147e
Liu J, Yang Y, Zhu W, Yi X, Dong Z, Xu X, Chen M, Yang K, Lu G, Jiang L, Liu Z (2016b) Nanoscale metal-organic frameworks for combined photodynamic and radiation therapy in cancer treatment. Biomaterials 97:1–9. https://doi.org/10.1016/j.biomaterials.2016.04.034
Liu L, Li E, Luo L, Zhao S, Li F, Wang J, Luo J, Zhao Z (2017) PSCA regulates IL-6 expression through p38/NF-kappaB signaling in prostate cancer. Prostate 77(14):1389–1400. https://doi.org/10.1002/pros.23399
Liu HN, Guo NN, Wang TT, Guo WW, Lin MT, Huang-Fu MY, Vakili MR, Xu WH, Chen JJ, Wei QC, Han M, Lavasanifar A, Gao JQ (2018a) Mitochondrial targeted doxorubicin-triphenylphosphonium delivered by hyaluronic acid modified and pH responsive nanocarriers to breast tumor: in vitro and in vivo studies. Mol Pharm 15(3):882–891. https://doi.org/10.1021/acs.molpharmaceut.7b00793
Liu M, Shi Z, Wang X, Zhang Y, Mo X, Jiang R, Liu Z, Fan L, Ma CG, Shi F (2018b) Simultaneous enhancement of red upconversion luminescence and CT contrast of NaGdF4:Yb, Er nanoparticles via Lu(3+) doping. Nanoscale 10(43):20279–20288. https://doi.org/10.1039/c8nr06968a
Lo YL, Lo PC, Chiu CC, Wang LF (2015) Folic acid linked chondroitin sulfate-polyethyleneimine copolymer based gene delivery system. J Biomed Nanotechnol 11(8):1385–1400
Loo JF, Lau PM, Kong SK, Ho HP (2017) An assay using localized surface plasmon resonance and gold nanorods functionalized with aptamers to sense the cytochrome-c released from apoptotic cancer cells for anti-cancer drug effect determination. Micromachines (Basel). https://doi.org/10.3390/mi8110338
Lugert S, Unterweger H, Muhlberger M, Janko C, Draack S, Ludwig F, Eberbeck D, Alexiou C, Friedrich RP (2019) Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models. Int J Nanomedicine 14:161–180. https://doi.org/10.2147/IJN.S187886
Luo L, Liu C, He T, Zeng L, Xing J, Xia Y, Pan Y, Gong C, Wu A (2018) Engineered fluorescent carbon dots as promising immune adjuvants to efficiently enhance cancer immunotherapy. Nanoscale 10(46):22035–22043. https://doi.org/10.1039/c8nr07252c
Lyer S, Singh R, Tietze R, Alexiou C (2015) Magnetic nanoparticles for magnetic drug targeting. Biomed Tech (Berl) 60(5):465–475. https://doi.org/10.1515/bmt-2015-0049
Lyra ME, Andreou M, Georgantzoglou A, Kordolaimi S, Lagopati N, Ploussi A, Salvara A-L, Vamvakas I (2013) Radionuclides used in nuclear medicine therapy–from production to dosimetry. Curr Med Imaging Rev 9(1):51–75
Maji SK, Mandal AK, Nguyen KT, Borah P, Zhao Y (2015) Cancer cell detection and therapeutics using peroxidase-active nanohybrid of gold nanoparticle-loaded mesoporous silica-coated graphene. ACS Appl Mater Interfaces 7(18):9807–9816. https://doi.org/10.1021/acsami.5b01758
Mancic L, Djukic-Vukovic A, Dinic I, Nikolic MG, Rabasovic MD, Krmpot AJ, Costa A, Trisic D, Lazarevic M, Mojovic L, Milosevic O (2018) NIR photo-driven upconversion in NaYF4:Yb, Er/PLGA particles for in vitro bioimaging of cancer cells. Mater Sci Eng C Mater Biol Appl 91:597–605. https://doi.org/10.1016/j.msec.2018.05.081
Marchetti C, Palaia I, Giorgini M, De Medici C, Iadarola R, Vertechy L, Domenici L, Di Donato V, Tomao F, Muzii L, Benedetti Panici P (2014) Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review. Onco Targets Ther 7:1223–1236. https://doi.org/10.2147/OTT.S40947
Mbatha LS, Singh M (2019) Starburst poly(amidoamine) dendrimer grafted gold nanoparticles as a scaffold for folic acid-targeted plasmid dna delivery in vitro. J Nanosci Nanotechnol 19(4):1959–1970. https://doi.org/10.1166/jnn.2019.15798
Mehra NK, Mishra V, Jain NK (2013) Receptor-based targeting of therapeutics. Ther Deliv 4(3):369–394. https://doi.org/10.4155/tde.13.6
Mitra RN, Doshi M, Zhang X, Tyus JC, Bengtsson N, Fletcher S, Page BD, Turkson J, Gesquiere AJ, Gunning PT, Walter GA, Santra S (2012) An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery. Biomaterials 33(5):1500–1508. https://doi.org/10.1016/j.biomaterials.2011.10.068
Mundy GR (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2(8):584–593. https://doi.org/10.1038/nrc867
Nakamura H, Nishimura T (2017) History, molecular features, and clinical importance of conventional serum biomarkers in lung cancer. Surg Today 47(9):1037–1059. https://doi.org/10.1007/s00595-017-1477-y
Nasrollahi F, Koh YR, Chen P, Varshosaz J, Khodadadi AA, Lim S (2019) Targeting graphene quantum dots to epidermal growth factor receptor for delivery of cisplatin and cellular imaging. Mater Sci Eng C Mater Biol Appl 94:247–257. https://doi.org/10.1016/j.msec.2018.09.020
Olson WC, Heston WD, Rajasekaran AK (2007) Clinical trials of cancer therapies targeting prostate-specific membrane antigen. Rev Recent Clin Trials 2(3):182–190
Pandey S, Thakur M, Mewada A, Anjarlekar D, Mishra N, Sharon M (2013) Carbon dots functionalized gold nanorod mediated delivery of doxorubicin: tri-functional nano-worms for drug delivery, photothermal therapy and bioimaging. J Mater Chem B 1(38):4972–4982. https://doi.org/10.1039/C3TB20761G
Pandey V, Gajbhiye KR, Soni V (2015) Lactoferrin-appended solid lipid nanoparticles of paclitaxel for effective management of bronchogenic carcinoma. Drug Deliv 22(2):199–205. https://doi.org/10.3109/10717544.2013.877100
Pang B, Yang X, Xia Y (2016) Putting gold nanocages to work for optical imaging, controlled release and cancer theranostics. Nanomedicine (Lond) 11(13):1715–1728. https://doi.org/10.2217/nnm-2016-0109
Park MH, Hong JE, Hwang CJ, Choi M, Choi JS, An YJ, Son DJ, Hong JT (2016) Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal. Arch Pharmacal Res 39(5):721–729. https://doi.org/10.1007/s12272-016-0735-7
Peng Y, Wang Z, Liu W, Zhang H, Zuo W, Tang H, Chen F, Wang B (2015) Size- and shape-dependent peroxidase-like catalytic activity of MnFe2O4 Nanoparticles and their applications in highly efficient colorimetric detection of target cancer cells. Dalton Trans 44(28):12871–12877. https://doi.org/10.1039/c5dt01585e
Perez-Ortiz M, Zapata-Urzua C, Acosta GA, Alvarez-Lueje A, Albericio F, Kogan MJ (2017) Gold nanoparticles as an efficient drug delivery system for GLP-1 peptides. Colloids Surf B Biointerfaces 158:25–32. https://doi.org/10.1016/j.colsurfb.2017.06.015
Perfezou M, Turner A, Merkoci A (2012) Cancer detection using nanoparticle-based sensors. Chem Soc Rev 41(7):2606–2622. https://doi.org/10.1039/c1cs15134g
Piawah S, Venook AP (2019) Targeted therapy for colorectal cancer metastases: a review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer. Cancer. https://doi.org/10.1002/cncr.32163
Pierrat P, Wang R, Kereselidze D, Lux M, Didier P, Kichler A, Pons F, Lebeau L (2015) Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials 51:290–302. https://doi.org/10.1016/j.biomaterials.2015.02.017
Plan Sangnier A, Aufaure R, Motte L, Wilhelm C, Guenin E, Lalatonne Y (2018) Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment. Beilstein J Nanotechnol 9:2947–2952. https://doi.org/10.3762/bjnano.9.273
Polasek M, Yang Y, Schuhle DT, Yaseen MA, Kim YR, Sung YS, Guimaraes AR, Caravan P (2017) Molecular MR imaging of fibrosis in a mouse model of pancreatic cancer. Sci Rep 7(1):8114. https://doi.org/10.1038/s41598-017-08838-6
Poon KA, Flagella K, Beyer J, Tibbitts J, Kaur S, Saad O, Yi JH, Girish S, Dybdal N, Reynolds T (2013) Preclinical safety profile of trastuzumab emtansine (T-DM1): mechanism of action of its cytotoxic component retained with improved tolerability. Toxicol Appl Pharmacol 273(2):298–313. https://doi.org/10.1016/j.taap.2013.09.003
Poonia M, Ramalingam K, Goyal S, Sidhu SK (2017) Nanotechnology in oral cancer: a comprehensive review. J Oral Maxillofac Pathol 21(3):407–414. https://doi.org/10.4103/jomfp.JOMFP_29_17
Pucci M, Lauriola M (2019) Chapter 18—resistance to EGFR targeting treatments in colorectal cancer. In: Dammacco F, Silvestris F (eds) Oncogenomics. Academic Press, Cambridge, pp 257–269. https://doi.org/10.1016/B978-0-12-811785-9.00018-1
Qiu W, Chen R, Chen X, Zhang H, Song L, Cui W, Zhang J, Ye D, Zhang Y, Wang Z (2018) Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer. Int J Nanomed 13:6809–6827. https://doi.org/10.2147/IJN.S177993
Ramezanzadeh E, Sadri K, Momennezhad M, Dolat E, Sazgarnia A (2018) Evaluation of EGFR-targeted gold/gold sulfide (GGS) nanoparticles as a theranostic agent in photothermal therapy. Mater Res Express 5(12):125401. https://doi.org/10.1088/2053-1591/aadfa0
Ramirez-Garcia G, Panikar SS, Lopez-Luke T, Piazza V, Honorato-Colin MA, Camacho-Villegas T, Hernandez-Gutierrez R, De la Rosa E (2018) An immunoconjugated up-conversion nanocomplex for selective imaging and photodynamic therapy against HER2-positive breast cancer. Nanoscale 10(21):10154–10165. https://doi.org/10.1039/c8nr01512k
Ren Q-Q, Bai L-Y, Zhang X-S, Ma Z-Y, Liu B, Zhao Y-D, Cao Y-C (2015) Preparation, modification, and application of hollow gold nanospheres. J Nanomater 2015:7. https://doi.org/10.1155/2015/534070
Scherer RL, McIntyre JO, Matrisian LM (2008) Imaging matrix metalloproteinases in cancer. Cancer Metastasis Rev 27(4):679–690. https://doi.org/10.1007/s10555-008-9152-9
Sebastian S, Settleman J, Reshkin SJ, Azzariti A, Bellizzi A, Paradiso A (2006) The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim Biophys Acta 1766(1):120–139. https://doi.org/10.1016/j.bbcan.2006.06.001
Shen C, Wang X, Zheng Z, Gao C, Chen X, Zhao S, Dai Z (2019) Doxorubicin and indocyanine green loaded superparamagnetic iron oxide nanoparticles with PEGylated phospholipid coating for magnetic resonance with fluorescence imaging and chemotherapy of glioma. Int J Nanomed 14:101–117. https://doi.org/10.2147/IJN.S173954
Shepard HM, Phillips GL, Thanos CD, Feldmann M (2017) Developments in therapy with monoclonal antibodies and related proteins. Clin Med (Lond) 17(3):220–232. https://doi.org/10.7861/clinmedicine.17-3-220
Shindo Y, Hazama S, Tsunedomi R, Suzuki N, Nagano H (2019) Novel biomarkers for personalized cancer immunotherapy. Cancers (Basel). https://doi.org/10.3390/cancers11091223
Sokolova E, Proshkina G, Kutova O, Shilova O, Ryabova A, Schulga A, Stremovskiy O, Zdobnova T, Balalaeva I, Deyev S (2016) Recombinant targeted toxin based on HER2-specific DARPin possesses a strong selective cytotoxic effect in vitro and a potent antitumor activity in vivo. J Control Release 233:48–56. https://doi.org/10.1016/j.jconrel.2016.05.020
Soleymani J, Hasanzadeh M, Somi MH, Ozkan SA, Jouyban A (2018) Targeting and sensing of some cancer cells using folate bioreceptor functionalized nitrogen-doped graphene quantum dots. Int J Biol Macromol 118:1021–1034. https://doi.org/10.1016/j.ijbiomac.2018.06.183
Song S, Chong Y, Fu H, Ning X, Shen H, Zhang Z (2018) HP-beta-CD functionalized Fe3O4/CNPs-based theranostic nanoplatform for pH/NIR responsive drug release and MR/NIRFL imaging-guided synergetic chemo/photothermal therapy of tumor. ACS Appl Mater Interfaces 10(40):33867–33878. https://doi.org/10.1021/acsami.8b09999
Song JL, Zhang Y, Dai YW, Hu JH, Zhu LX, Xu XL, Yu Y, Li H, Yao B, Zhou HX (2019) Polyelectrolyte-mediated nontoxic AgGaxIn1-xS2 QDs/low-density lipoprotein nanoprobe for selective 3d fluorescence imaging of cancer stem cells. ACS Appl Mater Interfaces 11(10):9884–9892. https://doi.org/10.1021/acsami.9b00121
Sonker N, Bajpai J, Bajpai AK (2018) Magnetically responsive release of 5-FU from superparamagnetic egg albumin coated iron oxide core-shell nanoparticles. J Drug Deliv Sci Technol 47:240–253. https://doi.org/10.1016/j.jddst.2018.07.021
Stambuk N, Konjevoda P, Turcic P, Sosic H, Aralica G, Babic D, Seiwerth S, Kastelan Z, Kujundzic RN, Wardega P, Zutelija JB, Gracanin AG, Gabricevic M (2019) Targeting tumor markers with antisense peptides: an example of human prostate specific antigen. Int J Mol Sci. https://doi.org/10.3390/ijms20092090
Stellavato A, Corsuto L, D’Agostino A, La Gatta A, Diana P, Bernini P, De Rosa M, Schiraldi C (2016) Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses re-activation. PLoS One 11(10):e0163510. https://doi.org/10.1371/journal.pone.0163510
Strebhardt K, Ullrich A (2008) Paul Ehrlich’s magic bullet concept: 100 years of progress. Nat Rev Cancer 8(6):473–480. https://doi.org/10.1038/nrc2394
Sun L, Wei Z, Chen H, Liu J, Guo J, Cao M, Wen T, Shi L (2014) Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications. Nanoscale 6(15):8878–8883. https://doi.org/10.1039/c4nr02312a
Sun S, Zhang L, Jiang K, Wu A, Lin H (2016) Toward high-efficient red emissive carbon dots: facile preparation, unique properties, and applications as multifunctional theranostic agents. Chem Mater 28(23):8659–8668. https://doi.org/10.1021/acs.chemmater.6b03695
Tao Y, Lin Y, Huang Z, Ren J, Qu X (2013) Incorporating graphene oxide and gold nanoclusters: a synergistic catalyst with surprisingly high peroxidase-like activity over a broad pH range and its application for cancer cell detection. Adv Mater 25(18):2594–2599. https://doi.org/10.1002/adma.201204419
Tao Y, Li M, Kim B, Auguste DT (2017) Incorporating gold nanoclusters and target-directed liposomes as a synergistic amplified colorimetric sensor for HER2-positive breast cancer cell detection. Theranostics 7(4):899–911. https://doi.org/10.7150/thno.17927
Teraoka S, Kakei Y, Akashi M, Iwata E, Hasegawa T, Miyawaki D, Sasaki R, Komori T (2018) Gold nanoparticles enhance X-ray irradiation-induced apoptosis in head and neck squamous cell carcinoma in vitro. Biomed Rep 9(5):415–420. https://doi.org/10.3892/br.2018.1142
Tian J, Ding L, Xu HJ, Shen Z, Ju H, Jia L, Bao L, Yu JS (2013) Cell-specific and pH-activatable rubyrin-loaded nanoparticles for highly selective near-infrared photodynamic therapy against cancer. J Am Chem Soc 135(50):18850–18858. https://doi.org/10.1021/ja408286k
Tseng SH, Chou MY, Chu IM (2015) Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy. Int J Nanomed 10:3663–3685. https://doi.org/10.2147/IJN.S80134
Turnis ME, Rooney CM (2010) Enhancement of dendritic cells as vaccines for cancer. Immunotherapy 2(6):847–862. https://doi.org/10.2217/imt.10.56
Verhoven B, Schlegel RA, Williamson P (1995) Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J Exp Med 182(5):1597–1601. https://doi.org/10.1084/jem.182.5.1597
Viel A, Bruselles A, Meccia E, Fornasarig M, Quaia M, Canzonieri V, Policicchio E, Urso ED, Agostini M, Genuardi M, Lucci-Cordisco E, Venesio T, Martayan A, Diodoro MG, Sanchez-Mete L, Stigliano V, Mazzei F, Grasso F, Giuliani A, Baiocchi M, Maestro R, Giannini G, Tartaglia M, Alexandrov LB, Bignami M (2017) A specific mutational signature associated with DNA 8-oxoguanine persistence in MUTYH-defective colorectal cancer. EBioMedicine 20:39–49. https://doi.org/10.1016/j.ebiom.2017.04.022
Villalobos P, Wistuba II (2017) Lung cancer biomarkers. Hematol Oncol Clin North Am 31(1):13–29. https://doi.org/10.1016/j.hoc.2016.08.006
Vu-Quang H, Vinding MS, Nielsen T, Ullisch MG, Nielsen NC, Nguyen DT, Kjems J (2019) Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging. Polymers (Basel). https://doi.org/10.3390/polym11040743
Wang C, Cheng L, Liu Z (2013a) Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics. Theranostics 3(5):317–330. https://doi.org/10.7150/thno.5284
Wang P, Nie X, Wang Y, Li Y, Ge C, Zhang L, Wang L, Bai R, Chen Z, Zhao Y, Chen C (2013b) Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-beta/Smad signaling pathway. Small 9(22):3799–3811. https://doi.org/10.1002/smll.201300607
Wang H, Han RL, Yang LM, Shi JH, Liu ZJ, Hu Y, Wang Y, Liu SJ, Gan Y (2016) Design and synthesis of core-shell-shell upconversion nanoparticles for NIR-induced drug release, photodynamic therapy, and cell imaging. ACS Appl Mater Interfaces 8(7):4416–4423. https://doi.org/10.1021/acsami.5b11197
Weaver O, Leung JWT (2018) Biomarkers and imaging of breast cancer. AJR Am J Roentgenol 210(2):271–278. https://doi.org/10.2214/AJR.17.18708
Weitman SD, Lark RH, Coney LR, Fort DW, Frasca V, Zurawski VR Jr, Kamen BA (1992) Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 52(12):3396–3401
WHO (2018) http://www.who.int/news-room/fact-sheets/detail/cancer. Accessed June 2019
Xia F, Niu J, Hong Y, Li C, Cao W, Wang L, Hou W, Liu Y, Cui D (2019) Matrix metallopeptidase 2 targeted delivery of gold nanostars decorated with IR-780 iodide for dual-modal imaging and enhanced photothermal/photodynamic therapy. Acta Biomater 89:289–299. https://doi.org/10.1016/j.actbio.2019.03.008
Xiang D, Zheng C, Zhou SF, Qiao S, Tran PH, Pu C, Li Y, Kong L, Kouzani AZ, Lin J, Liu K, Li L, Shigdar S, Duan W (2015) Superior performance of aptamer in tumor penetration over antibody: implication of aptamer-based theranostics in solid tumors. Theranostics 5(10):1083–1097. https://doi.org/10.7150/thno.11711
Xianyu Y, Xie Y, Wang N, Wang Z, Jiang X (2015) A dispersion-dominated chromogenic strategy for colorimetric sensing of glutathione at the nanomolar level using gold nanoparticles. Small 11(41):5510–5514. https://doi.org/10.1002/smll.201500903
Xiao Z, Levy-Nissenbaum E, Alexis F, Luptak A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R, Farokhzad OC (2012) Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano 6(1):696–704. https://doi.org/10.1021/nn204165v
Yang S, You Q, Yang L, Li P, Lu Q, Wang S, Tan F, Ji Y, Li N (2019) Rodlike MSN@Au nanohybrid-modified supermolecular photosensitizer for NIRF/MSOT/CT/MR quadmodal imaging-guided photothermal/photodynamic cancer therapy. ACS Appl Mater Interfaces 11(7):6777–6788. https://doi.org/10.1021/acsami.8b19565
Yiu AJ, Yiu CY (2016) Biomarkers in colorectal cancer. Anticancer Res 36(3):1093–1102
Youssoufian H, Hicklin DJ, Rowinsky EK (2007) Review: monoclonal antibodies to the vascular endothelial growth factor receptor-2 in cancer therapy. Clin Cancer Res 13(18 Pt 2):5544s–5548s. https://doi.org/10.1158/1078-0432.CCR-07-1107
Yuan R, Rao T, Cheng F, Yu WM, Ruan Y, Zhang XB, Larre S (2018) Quantum dot-based fluorescent probes for targeted imaging of the EJ human bladder urothelial cancer cell line. Exp Ther Med 16(6):4779–4783. https://doi.org/10.3892/etm.2018.6805
Zarschler K, Rocks L, Licciardello N, Boselli L, Polo E, Garcia KP, De Cola L, Stephan H, Dawson KA (2016) Ultrasmall inorganic nanoparticles: state-of-the-art and perspectives for biomedical applications. Nanomedicine 12(6):1663–1701. https://doi.org/10.1016/j.nano.2016.02.019
Zhang M, Kim HS, Jin T, Woo J, Piao YJ, Moon WK (2017) Near-infrared photothermal therapy using anti-EGFR-gold nanorod conjugates for triple negative breast cancer. Oncotarget 8(49):86566–86575. https://doi.org/10.18632/oncotarget.21243
Zhang M, Wang W, Wu F, Graveran K, Zhang J, Wu C (2018) Black phosphorus quantum dots gated, carbon-coated Fe3O4 nanocapsules (BPQDs@ss-Fe3O4 @C) with low premature release could enable imaging-guided cancer combination therapy. Chemistry 24(49):12890–12901. https://doi.org/10.1002/chem.201801085
Zhang Q, Deng S, Liu J, Zhong X, He J, Chen X, Feng B, Chen Y, Ostrikov K (2019) Cancer-targeting graphene quantum dots: fluorescence quantum yields, stability, and cell selectivity. Adv Func Mater 29(5):1805860. https://doi.org/10.1002/adfm.201805860
Zhao N, Wu B, Hu X, Xing D (2017) NIR-triggered high-efficient photodynamic and chemo-cascade therapy using caspase-3 responsive functionalized upconversion nanoparticles. Biomaterials 141:40–49. https://doi.org/10.1016/j.biomaterials.2017.06.031
Zhao C, Song X, Jin W, Wu F, Zhang Q, Zhang M, Zhou N, Shen J (2019a) Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles. Anal Chim Acta 1056:108–116. https://doi.org/10.1016/j.aca.2018.12.045
Zhao L, Li Y, Zhu J, Sun N, Song N, Xing Y, Huang H, Zhao J (2019b) Chlorotoxin peptide-functionalized polyethylenimine-entrapped gold nanoparticles for glioma SPECT/CT imaging and radionuclide therapy. J Nanobiotechnol 17(1):30. https://doi.org/10.1186/s12951-019-0462-6
Zhao S, Sun S, Jiang K, Wang YH, Liu Y, Wu S, Li ZJ, Shu QH, Lin HW (2019c) In situ synthesis of fluorescent mesoporous silica-carbon dot nanohybrids featuring folate receptor-overexpressing cancer cell targeting and drug delivery. Nano-Micro Lett 11(1):13. https://doi.org/10.1007/s40820-019-0263-3
Zhu DM, Xie W, Xiao YS, Suo M, Zan MH, Liao QQ, Hu XJ, Chen LB, Chen B, Wu WT, Ji LW, Huang HM, Guo SS, Zhao XZ, Liu QY, Liu W (2018) Erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy. Nanotechnology 29(8):084002. https://doi.org/10.1088/1361-6528/aa9ca1
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Singh, R. Nanotechnology based therapeutic application in cancer diagnosis and therapy. 3 Biotech 9, 415 (2019). https://doi.org/10.1007/s13205-019-1940-0
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DOI: https://doi.org/10.1007/s13205-019-1940-0