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Epigenetic Changes in Carcinogenesis of Gallbladder

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Gallbladder cancer (GBC) is a lethal and a common malignancy affecting mostly females. There are restricted high incidence pockets across the world and in northern India highest incidence of GBC is reported from the Gangetic belt. The etiology of this disease remains largely unknown though several risk factors have been stated. The genetic aberrations in GBC involving mutations in tumor suppressor genes and oncogenes have been reported in literature. However, there is scarcity of data regarding epigenetic changes that may also be involved in gallbladder carcinogenesis. This review attempts to summarize our current understanding of the epigenetic changes in GBC.

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Authors and Affiliations

  1. Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, U.P., India

    Mallika Tewari, Amit Agarwal & Hari S. Shukla

  2. Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    R. R. Mishra

  3. Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    R. N. Meena

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  1. Mallika Tewari
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  2. Amit Agarwal
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  3. R. R. Mishra
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Correspondence to Mallika Tewari.

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Tewari, M., Agarwal, A., Mishra, R.R. et al. Epigenetic Changes in Carcinogenesis of Gallbladder. Indian J Surg Oncol 4, 356–361 (2013). https://doi.org/10.1007/s13193-013-0240-0

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