Skip to main content
SpringerLink
Log in

Increased 68 Ga-PSMA-11 Bone Marrow and Splenic Uptake in a Case of Erythroid Myelodysplasia

  • Interesting image
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

We describe the case of an 82-year-old man who underwent 68 Ga-prostate-specific membrane antigen-11 (68 Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) for the restaging of prostate carcinoma. 68 Ga-PSMA-11 PET/CT unexpectedly showed increased tracer uptake homogenously involving the axial and appendicular bone marrow and the spleen, not characteristic for metastatic prostate disease. Further investigations revealed that 2 months before the patient underwent bone marrow biopsy, which showed the occurrence of monolinear myelodysplasia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data Availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

References

  1. Hofman MS, Hicks RJ, Maurer T, Eiber M. Prostate-specific membrane antigen PET: clinical utility in prostate cancer, normal patterns, pearls, and pitfalls. Radiographics. 2018;38:200–17.

    Article  Google Scholar 

  2. Silver DA, Pellicer I, Fair WR, Heston WD, Cordon-Cardo C. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res. 1997;3:81–5.

    CAS  PubMed  Google Scholar 

  3. Chang SS, O’Keefe DS, Bacich DJ, Reuter VE, Heston WD, Gaudin PB. Prostate-specific membrane antigen is produced in tumor-associated neovasculature. Clin Cancer Res. 1999;5:2674–81.

    CAS  PubMed  Google Scholar 

  4. Aguayo A, Giles F, Albitar M. Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes. Leuk Lymphoma. 2003;44:213–22.

    Article  CAS  Google Scholar 

  5. Acksteiner C, Sounness B. Incidental finding of acute lymphocytic leukemia in a prostate-specific membrane antigen PET/CT. Clin Nucl Med. 2019;44:e529–31.

    Article  Google Scholar 

  6. Arslan İ, Demirci E, Özkara S, Taşdelen N, Alan SN. Myelodysplastic syndrome presenting with diffuse bone marrow uptake on 68Ga-PSMA PET/CT. Clin Nucl Med. 2020;45:330–3.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Health Sciences (DISSAL), University of Genova, Genova, Italy

    Maria Isabella Donegani, Stefano Raffa, Alberto Miceli & Silvia Morbelli

  2. Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy

    Silvia Morbelli & Matteo Bauckneht

Authors
  1. Maria Isabella Donegani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefano Raffa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alberto Miceli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Silvia Morbelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Matteo Bauckneht
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization: M.B., M.I.D. Writing the original draft preparation: M.I.D. Revision of the original draft: M.B., S.M., S.R. Supervision: M.B.. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Matteo Bauckneht.

Ethics declarations

Conflict of Interests

Silvia Morbelli received speaker honoraria from General Electric and Eli-Lilly. Maria Isabella Donegani, Stefano Raffa, Alberto Miceli and Matteo Bauckneht declare they have no conflict of interests.

Ethics Approval and Consent to Participate

All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individuals.

Consent for Publication

The patient provided written informed consent for the publication of this case.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Donegani, M.I., Raffa, S., Miceli, A. et al. Increased 68 Ga-PSMA-11 Bone Marrow and Splenic Uptake in a Case of Erythroid Myelodysplasia. Nucl Med Mol Imaging 55, 323–324 (2021). https://doi.org/10.1007/s13139-021-00718-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-021-00718-2

Keywords

Search

Navigation