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Comparative Analysis of Lung Perfusion Scan and SPECT/CT for the Evaluation of Functional Lung Capacity

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Abstract

Purpose

This study aimed to compare lung perfusion scan with single photon emission computed tomography/computed tomography (SPECT/CT) for the evaluation of lung function and to elucidate the most appropriate modality for the prediction of postoperative lung function in patients with lung cancer.

Methods

A total of 181 patients underwent Tc-99m macroaggregated albumin lung perfusion scan and SPECT/CT to examine the ratio of diseased lung and diseased lobe. Forty-one patients with lung cancer underwent both preoperative and postoperative pulmonary function tests within 1 month to predict postoperative pulmonary function. Predicted postoperative forced expiratory volume in 1 s (ppoFEV1) was calculated by the % radioactivity of lung perfusion scan and SPECT, and the % volume of the residual lung, assessed on CT.

Results

The ratios of diseased lung as seen on lung perfusion scan and SPECT showed significant correlation, but neither modality correlated with CT. The ratios of the diseased lung and diseased lobe based on CT were higher than the ratios based on either perfusion scan or SPECT, because CT overestimated the function of the diseased area. The lobar ratio of both upper lobes was lower based on the perfusion scan than on SPECT but was higher for both lower lobes. Actual postoperative FEV1 showed significant correlation with ppoFEV1 based on lung perfusion SPECT and perfusion scan.

Conclusions

We suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function.

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Acknowledgements

The authors would like to thank the members of the Department of Nuclear Medicine, National Cancer Center for their technical assistance and support.

Funding

This work was supported by a grant from the National Cancer Center (NCC-1810201).

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Authors and Affiliations

  1. Department of Nuclear Medicine, National Cancer Center, Goyang, Republic of Korea

    Hoon Young Suh, Sohyun Park, Tae Sung Kim & Seok-Ki Kim

  2. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea

    Hoon Young Suh, Hyun Gee Ryoo & Ji-Young Kim

  3. Department of Thoracic Surgery, National Cancer Center, Goyang, Republic of Korea

    Jong Mog Lee, Moon Soo Kim & Hee Chul Yang

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  1. Hoon Young Suh
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  2. Sohyun Park
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Correspondence to Seok-Ki Kim.

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Conflict of Interest

Hoon Young Suh, Sohyun Park, Hyun Gee Ryoo, Ji-Young Kim, Tae Sung Kim, Jong Mog Lee, Moon Soo Kim, Hee Chul Yang, and Seok-Ki Kim declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

The institutional review board of our institute approved this retrospective study (IRB No. 2019-0270-0001), and the requirement to obtain informed consent was waived.

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Suh, H.Y., Park, S., Ryoo, H.G. et al. Comparative Analysis of Lung Perfusion Scan and SPECT/CT for the Evaluation of Functional Lung Capacity. Nucl Med Mol Imaging 53, 406–413 (2019). https://doi.org/10.1007/s13139-019-00617-7

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  • DOI: https://doi.org/10.1007/s13139-019-00617-7

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