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Bone and Calcified Soft Tissue Metastases of Medullary Thyroid Carcinoma Better Characterized on 18F-Fluoride PET/CT than on 68Ga-Dotatate PET/CT

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Abstract

Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroid carcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervical radiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with 18F-fluoride (18F-NaF) and 68Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastatic disease monitoring. We found that the MTC bone metastases and soft tissue calcified metastases were better characterized on 18F-NaF PET/CT than on 68Ga-dotatate PET/CT. This case illustrates that the 18F-NaF PET/CT could be helpful not only to the detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.

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Authors and Affiliations

  1. Division of Nuclear Medicine, São Paulo Cancer Institute (ICESP), Av. Dr. Arnaldo, 251, 4° SS, Cerqueira César, São Paulo, SP, 01246-000, Brazil

    Paulo Schiavom Duarte, Heitor Naoki Sado, Marcelo Tatit Sapienza & Carlos Alberto Buchpiguel

  2. Division of Endocrinology, São Paulo Cancer Institute (ICESP), São Paulo, Brazil

    Luciana Audi de Castroneves & Ana Amélia Fialho de Oliveira Hoff

Authors
  1. Paulo Schiavom Duarte
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  2. Luciana Audi de Castroneves
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  3. Heitor Naoki Sado
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  4. Marcelo Tatit Sapienza
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  5. Ana Amélia Fialho de Oliveira Hoff
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  6. Carlos Alberto Buchpiguel
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Correspondence to Paulo Schiavom Duarte.

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Conflict of Interest

Paulo Schiavom Duarte, Luciana Audi de Castroneves, Heitor Naoki Sado, Marcelo Tatit Sapienza, Ana Amélia Fialho de Oliveira Hoff, and Carlos Alberto Buchpiguel declare no conflict of interest.

Ethical Approval

All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

The institutional review board of our institute approved this case report, and the requirement to obtain informed consent was waived.

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Duarte, P.S., de Castroneves, L.A., Sado, H.N. et al. Bone and Calcified Soft Tissue Metastases of Medullary Thyroid Carcinoma Better Characterized on 18F-Fluoride PET/CT than on 68Ga-Dotatate PET/CT. Nucl Med Mol Imaging 52, 318–323 (2018). https://doi.org/10.1007/s13139-018-0527-8

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  • DOI: https://doi.org/10.1007/s13139-018-0527-8

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