Skip to main content
SpringerLink
Log in

Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities

  • Original Article
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and the therapeutic effect was validated using different imaging methods.

Methods

Male SD rats (n = 18, 6 weeks old) were randomly assigned into three groups: Group 1 as control, Group 2 without any ligation of distal femoral artery, and Group 3 with temporary ligation of the distal femoral artery. RR1022 sarcoma cell lines were inoculated into thigh muscle. After 1 week, CMH was injected into the proximal femoral artery. Different imaging modalities were performed during a 3-week follow-up.

Results

The tumor size was significantly (P < 0.001) decreased in both Group 2 and Group 3 (P < 0.001) after selective arterial embolization therapy. 18F-FDG-PET/CT revealed decreased intensity of 18F-FDG uptake in tumors. The accumulation status of 125I-CMH near the tumor was verified by gamma camera.

Conclusions

Appropriate selective arterial embolization therapy with CMH was.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Yao FY, Kerlan Jr RK, Hirose R, Davern 3rd TJ, Bass NM, Feng S, et al. Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis. Hepatology. 2008;48:819–27.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Kneuertz PJ, Marsh JW, de Jong MC, Covert K, Hyder O, Hirose K, et al. Improvements in quality of life after surgery for benign hepatic tumors: Results from a dual center analysis. Surgery. 2012;152:193–201.

    Article  PubMed  Google Scholar 

  3. Garvey EM, Gray RJ, Wasif N, Casey WJ, Rebecca AM, Kreymerman P, et al. Neoadjuvant therapy and breast cancer surgery: a closer look at postoperative complications. Am J Surg. 2013;206:894–8.

    Article  PubMed  Google Scholar 

  4. J-P G’r, Azria D, Gourgou-Bourgade S, et al. Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol. 2010;28:1638–44.

    Article  Google Scholar 

  5. Aschele C, Cionini L, Lonardi S, et al. Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: Pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol. 2011;29:2773–80.

    Article  CAS  PubMed  Google Scholar 

  6. Dewdney A, Cunningham D, Tabernero J, et al. Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C). J Clin Oncol. 2012;30:1620–7.

    Article  CAS  PubMed  Google Scholar 

  7. Singla A, Deshaies EM, Melnyk V, Toshkezi G, Swarnkar A, Choi H, et al. Controversies in the role of preoperative embolization in meningioma management. Neurosurg Focus. 2013;35:E17.

    Article  PubMed  Google Scholar 

  8. Cheng X, Sun P, Hu QG, Song ZF, Xiong J, Zheng QC. Transarterial (chemo) embolization for curative resection of hepatocellular carcinoma: a systematic review and meta-analyses. J Cancer Res Clin Oncol. 2014;140:1159–70.

    Article  PubMed  Google Scholar 

  9. Leyon JJ, Littlehales T, Rangarajan B, Hoey ET, Ganeshan A. Endovascular embolization: review of currently available embolization agents. Curr Probl Diagn Radiol. 2014;43:35–53.

    Article  PubMed  Google Scholar 

  10. Wang JJ, Zeng ZW, Xiao RZ, Xie T, Zhou GL, Zhan XR, et al. Recent advances of chitosan nano particles as drug carriers. Int J Nanomedicine. 2011;6:765–74.

    PubMed Central  CAS  PubMed  Google Scholar 

  11. Chae MJ, Lee ST, Kim JY, Woo GS, Jung WS, Chun KS, et al. Small Animal PET Imaging with [124I] FIAU for Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression in a Hepatoma Model. Nucl Med Mol Imaging. 2008;42:235–45.

    Google Scholar 

  12. Lin CY, Chen JH, Liang JA, Lin CC, Jeng LB, Kao CH. 18 F-FDG PET or PET/CT for detecting extrahepatic metastases or recurrent hepatocellular carcinoma: a systematic review and meta-analysis. Eur J Radiol. 2012;81:2417–22.

    Article  PubMed  Google Scholar 

  13. Addley HC, Griffin N, Shaw AS, Mannelli L, Parker RA, Aitken S, et al. Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation. Clin Radiol. 2011;66:349–56.

    Article  CAS  PubMed  Google Scholar 

  14. Ma X, Liu Z, Yang X, Gao Q, Zhu S, Qin C, et al. Dual-modality monitoring of tumor response to cyclophosphamide therapy in mice with bioluminescence imaging and small-animal positron emission tomography. Mol Imaging. 2011;10:278–83.

    CAS  PubMed  Google Scholar 

  15. Thompson SM, Callstrom MR, Knudsen B, Anderson JL, Butters KA, Grande JP, et al. AS30D model of hepatocellular carcinoma: tumorigenicity and preliminary characterization by imaging, histopathology, and immunohistochemistry. Cardiovasc Intervent Radiol. 2013;36:198–203.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Gutzeit A, van Schie B, Schoch E, Hergan K, Graf N, Binkert CA. Feasibility and safety of vascular closure devices in an antegrade approach to either the common femoral artery or the superficial femoral artery. Cardiovasc Intervent Radiol. 2012;35:1036–40.

    Article  PubMed  Google Scholar 

  17. Oliva MR, Saini S. Liver cancer imaging: role of CT, MRI, US and PET. Cancer Imaging. 2004. doi:10.1102/1470-7330.2004.0011.

    PubMed Central  PubMed  Google Scholar 

  18. Weber W, Weber J, Senekowitsch-Schmidtke R. Therapeutic effect of m-[131I]- and m-[125I] iodobenzylguanidine on neuroblastoma multicellular tumor spheroids of different sizes. Cancer Res. 1996;56:5428–34.

    CAS  PubMed  Google Scholar 

  19. Maini CL, Scelsa MG, Fiumara C, Tofani A, Sciuto R, Tipaldi L, et al. Superselective intra-arterial radiometabolic therapy with I-131 lipiodol in hepatocellular carcinoma. Clin Nucl Med. 1996;21:221–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported by National Research Foundation of Korea and funded by the Ministry of Science, ICT and Future Planning; 2012M2A2A7014020, 2012M2A2A7035779 and 2011-0028581.

Ethical Statement

This study was approved by the animal ethics committee in our hospital and performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Conflict of Interest

Tai Kyoung Lee, JeongIl Kwon, Kyung Sook Na, Hwan-Seok Jeong, Hyosook Hwang, Phil-Sun Oh, Dong Hyun Kim, Kyu Yun Jang, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea

    Tai Kyoung Lee, Kyung Sook Na, Hwan-Seok Jeong, Hyosook Hwang, Phil-Sun Oh, Seok Tae Lim, Myung-Hee Sohn & Hwan-Jeong Jeong

  2. Kai Bio Tech, Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea

    JeongIl Kwon & Dong Hyun Kim

  3. Department of Pathology, Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea

    Kyu Yun Jang

  4. Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Geonji-ro, Dukjin-gu, Jeonju, Republic of Korea

    Hwan-Jeong Jeong

Authors
  1. Tai Kyoung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JeongIl Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung Sook Na
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hwan-Seok Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hyosook Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Phil-Sun Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dong Hyun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kyu Yun Jang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Seok Tae Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Myung-Hee Sohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Hwan-Jeong Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hwan-Jeong Jeong.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, T.K., Kwon, J., Na, K.S. et al. Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities. Nucl Med Mol Imaging 49, 191–199 (2015). https://doi.org/10.1007/s13139-014-0316-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-014-0316-y

Keywords

Search

Navigation