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Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast

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Abstract

Purpose

The purpose of this study was to investigate the correlation of primary tumor FDG uptake to clinicopathological prognostic factors in invasive ductal carcinoma of the breast.

Methods

We retrospectively reviewed 136 of 215 female patients with pathologically proven invasive ductal breast cancer from January 2008 to December 2011 who underwent F-18 FDG PET/CT for initial staging and follow-up after curative treatment with analysis of estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor 2 (HER2). The maximum standardized uptake value (SUVmax) of the primary breast tumor was measured and compared with hormonal receptor and HER2 overexpression status.

Results

The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: tumor size, histologic grade, TNM stage, negativity of ER, negativity of PR, HER2 overexpression and triple negativity. The recurrent group with non-triple negative cancer had a higher SUVmax compared with the non-recurrent group, though no significant difference in FDG uptake was noted between the recurrence and non-recurrent groups in subjects with triple-negative cancer. Lymph node involvement was the independent risk factor for cancer recurrence in the multivariate analysis.

Conclusions

In conclusion, high FDG uptake in primary breast tumors is significantly correlated with clinicopathological factors, such as tumor size, histologic grade, TNM stage, negativity of the hormonal receptor, HER2 overexpression and triple negativity. Therefore, FDG PET/CT is a helpful prognostic tool to direct the further management of patients with breast cancer.

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Disclosure

Conflict of Interest

Il Jo, Seok Kil Zeon, Sung Hoon Kim, Hae Won Kim, Sun Hee Kang and Su Jin Kim declare that they have no conflicts of interest.

Ethics Statement

This study was approved by Institutional Review Board of Keimyung University Dongsan Hospital. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Keimyung University, School of Medicine, Daegu, Republic of Korea

    I. Jo, Sung Hoon Kim & Hae Won Kim

  2. Department of Surgery, Keimyung University, School of Medicine, Daegu, Republic of Korea

    Sun Hee Kang

  3. Department of Pathology, Keimyung University, School of Medicine, Daegu, Republic of Korea

    Sun Young Kwon

  4. Department of Nuclear Medicine, Bundang Jesaeng General Hospital, Seohyeon-dong 255-2, Seongnam, Republic of Korea

    Seok Kil Zeon

  5. Department of Anesthesiology and Pain Medicine, Dongguk University, School of Medicine, Gyeongju, Republic of Korea

    Su Jin Kim

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  1. I. Jo
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  2. Seok Kil Zeon
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  3. Sung Hoon Kim
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  4. Hae Won Kim
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Correspondence to Seok Kil Zeon.

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Jo, I., Zeon, S.K., Kim, S.H. et al. Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast. Nucl Med Mol Imaging 49, 19–25 (2015). https://doi.org/10.1007/s13139-014-0296-y

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  • DOI: https://doi.org/10.1007/s13139-014-0296-y

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