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Translational Research Using a Mouse Model of Intracranial Aneurysm

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Abstract

We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in this model show an infiltration with inflammatory cells. This mouse model can be used to study the mechanisms and the potential preventive treatments for aneurysmal rupture.

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Acknowledgments

The project described was supported by grant numbers R01NS055876 (TH) and R01NS082280 (TH) from the National Institute of Neurological Disorders and Stroke (NIH/NINDS) and the Brain Aneurysm Foundation Shirley Dudek Demmer Chair of Research (KS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Institutes of Health, or the Brain Aneurysm Foundation.

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Authors and Affiliations

  1. Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, No. 3C-38, San Francisco, CA, 94110, USA

    Kosuke Wada, Kenji Shimada, Fumiaki Shikata, Atsushi Kuwabara & Tomoki Hashimoto

  2. Department of Anesthesia and Perioperative Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka, 431-3192, Japan

    Hiroshi Makino

Authors
  1. Kosuke Wada
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  2. Hiroshi Makino
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  3. Kenji Shimada
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  4. Fumiaki Shikata
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  5. Atsushi Kuwabara
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  6. Tomoki Hashimoto
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Corresponding author

Correspondence to Tomoki Hashimoto.

Additional information

Kosuke Wada and Hiroshi Makino contributed equally to the project.

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Wada, K., Makino, H., Shimada, K. et al. Translational Research Using a Mouse Model of Intracranial Aneurysm. Transl. Stroke Res. 5, 248–251 (2014). https://doi.org/10.1007/s12975-013-0296-8

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  • DOI: https://doi.org/10.1007/s12975-013-0296-8

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