Abstract
Neonatal hepatitis with acute liver failure due to varied etiology including various infections is reported in the past. Scrub typhus as a cause of neonatal hepatitis has rarely been reported in literature. A high index of clinical suspicion is required for early diagnosis and timely treatment. Severity and prognosis of the disease varies widely because several different strains of Orientia tsutsugamushi exist with different virulence. Delayed diagnosis can result in complication and significant morbidity and mortality. Here, we report three cases of neonatal hepatitis with acute liver failure caused by scrub typhus to increase awareness.
References
Yachha SK. Consensus report on neonatal cholestasis syndrome. Indian Pediatr. 2000;37:845–51.
Rahi M, Gupte MD, Bhargava A, Varghese GM, Arora R. DHR-ICMR guidelines for diagnosis & management of rickettsial diseases in India. Indian J Med Res. 2015;141:417–22.
Rathi N, Rathi A. Rickettsial infections: Indian perspective. Indian Pediatr. 2010;47:157–64.
Sundaram SS, Alonso EM, Narkewicz MR, Zhang S, Squires RH, PALF study group. Characterization and outcomes of young infants with acute liver failure. J Pediatr. 2011;159:813–8.
Taylor SA, Whitington PA. Neonatal acute liver failure. Liver Transpl. 2016;22:677–85.
Varghese GM, Trowbridge P, Janardhanan J, et al. Clinical profile and improving mortality trend of scrub typhus in South India. Int J Infect Dis. 2014;23:39–43.
Roopa KS, Karthika K, Sugumar M, Bammigatti C, Shamanna SB, Harish BN. Serodiagnosis of scrub typhus at a tertiary care hospital from southern India. J Clin Diagn Res. 2015;9:DC05–7.
Blacksell SD, Tanganuchitcharnchai A, Nawtaisong P, et al. Diagnostic accuracy of the in bios scrub typhus detect enzyme-linked immunoassay for the detection of IgM antibodies in northern Thailand. Clin Vaccine Immunol. 2015;23:148–54.
Shah I, Bang V, Shah V, Vaidya V. Pediatric Scrub Typhus. JK Science. 2010;12(2):88–90.
Peter JV, Sudarsan TI, Prakash JAJ, Varghese GM. Severe scrub typhus infection: clinical features, diagnostic challenges and management. World J Crit Care Med. 2015;4:244–50.
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Vajpayee, S., Gupta, R.K. & Gupta, M.L. Scrub typhus causing neonatal hepatitis with acute liver failure—A case series. Indian J Gastroenterol 36, 239–242 (2017). https://doi.org/10.1007/s12664-017-0761-5
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DOI: https://doi.org/10.1007/s12664-017-0761-5