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Bone mineralization in children with Wilson’s disease

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Abstract

Background

The goal of this study was to determine bone mineralization in children with Wilson’s disease (WD).

Methods

Twenty-seven patients (16 males) and two age- and gender-matched healthy children for each patient were enrolled in the study. Bone mineral content (BMC, grams) and density (BMD, g/cm2) at lumbar 1–4 vertebrae were measured by dual-energy X-ray absorptiometry. Urinary calcium excretion was calculated in 19 patients. The effect of cirrhosis and hypercalciuria on BMC and BMD was also evaluated in WD patients.

Results

There was no statistically significant difference between patients and healthy controls regarding mean BMC (33.0 ± 13.9 vs. 35.8 ± 13.8 g) (p = 0.940) and mean BMD values (0.66 ± 0.16 vs. 0.71 ± 0.18 g/cm2) (p = 0.269), respectively. Nine (47.4 %) patients had hypercalciuria. Hypercalciuric patients had statistically significant lower BMC and BMD values than those without hypercalciuria. A significant difference continued to be present after age, weight, height, and pubertal stage adjustment was done, but disappeared after weight, height, follow up duration, and pubertal stage adjustment was done. The presence of cirrhosis did not affect BMC and BMD significantly in WD patients.

Conclusions

BMC and BMD in children with WD were normal. The presence of hypercalciuria but not cirrhosis may affect BMC and BMD negatively in the patients.

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Conflict of interest

AC, HÖ, AY, İNS-T, HD, and FG have no conflict of interest to report.

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Ethics statement

The study was performed in a manner that conforms with the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning Human and Animal Rights, and the authors followed the policy concerning Informed Consent as shown on Springer.com.

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Authors and Affiliations

  1. School of Medicine, Department of Pediatrics, Gastroenterology, Hepatology and Nutrition Unit, Ihsan Dogramaci Children’s Hospital, Hacettepe University, 06100, Ankara, Turkey

    Ahmet Çetinkaya, Hasan Özen, Aysel Yüce, İnci Nur Saltık-Temizel, Hülya Demir & Figen Gürakan

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  1. Ahmet Çetinkaya
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  2. Hasan Özen
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  3. Aysel Yüce
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  4. İnci Nur Saltık-Temizel
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  5. Hülya Demir
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  6. Figen Gürakan
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Correspondence to Hasan Özen.

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Çetinkaya, A., Özen, H., Yüce, A. et al. Bone mineralization in children with Wilson’s disease. Indian J Gastroenterol 33, 427–431 (2014). https://doi.org/10.1007/s12664-014-0468-9

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  • DOI: https://doi.org/10.1007/s12664-014-0468-9

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