Skip to main content

Advertisement

SpringerLink
Log in

SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers

  • Original Article
  • Published:
Indian Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

A single nucleotide polymorphism (SNP) in the stromal cell-derived factor-1 (SDF-1) gene at position 801 (G>A) is associated with susceptibility to certain tumors. This study aimed to investigate an association between this SNP and colorectal and gastric cancers in an Iranian population.

Method

Genotype and allele frequencies of SDF-1 801 G>A were assessed using polymerase chain reaction-restriction fragment length polymorphism in 109 patients with colorectal cancer, 124 with gastric cancer, and 262 normal control volunteers.

Results

No statistically significant difference was observed in the frequencies of genotypes and alleles between patients and controls (p > 0.05).

Conclusion

SDF-1 gene polymorphism at position 801 (G>A) was not associated with colorectal and gastric cancers in Southern Iranian patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Selgrad M, Bornschein J, Rokkas TH, Malfertheiner P. Clinical aspects of gastric cancer and Helicobacter pylori—screening, prevention, and treatment. Helicobacter. 2010;15:40–5.

    Article  PubMed  Google Scholar 

  2. Marcus B, Arenberg D, Lee J, et al. Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma. Cancer. 2004;101:2779–87.

    Article  PubMed  Google Scholar 

  3. Uchida D, Begum NM, Tomizuka Y, et al. Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma. Lab Invest. 2004;84:1538–46.

    Article  PubMed  CAS  Google Scholar 

  4. Razmkhah M, Talei AR, Doroudchi M, Khalili-Azad T, Ghaderi A. Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. Cancer Lett. 2005;225:261–6.

    Article  PubMed  CAS  Google Scholar 

  5. Khademi B, Razmkhah M, Erfani N, Gharagozloo M, Ghaderi A. SDF-1 and CCR5 genes polymorphism in patients with head and neck cancer. Pathol Oncol Res. 2008;14:45–50.

    Article  PubMed  CAS  Google Scholar 

  6. Razmkhah M, Doroudchi M, Ghayumi SM, Erfani N, Ghaderi A. Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer. Lung Cancer. 2005;49:311–5.

    Article  PubMed  Google Scholar 

  7. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med. 1996;184:1101–9.

    Article  PubMed  CAS  Google Scholar 

  8. Sun X, Cheng G, Hao M, et al. CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 2010;29:709–22.

    Article  PubMed  CAS  Google Scholar 

  9. Perissinotto E, Cavalloni G, Leone F, et al. Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. Clin Cancer Res. 2005;11:490–7.

    PubMed  CAS  Google Scholar 

  10. Luker KE, Luker GD. Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett. 2005;23:1–12.

    Google Scholar 

  11. Kang H, Watkins G, Parr C, Douglas-Jones A, Mansel RE, Jiang WG. Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer. Breast Cancer Res. 2005;7:402–10.

    Article  Google Scholar 

  12. Wang J, Sun Y, Song W, et al. Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. Cell Signal. 2005;17:1578–92.

    Article  PubMed  CAS  Google Scholar 

  13. Balkwill F. Cancer and the chemokine network. Nature Rev Cancer. 2004;4:540–50.

    Article  CAS  Google Scholar 

  14. Martinez A, Kapas S, Miller MJ, Ward Y, Cuttitta F. Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology. 2000;141:406–11.

    Article  PubMed  CAS  Google Scholar 

  15. Watanabe MA, de Oliveira Cavassin GG, Orellana MD, et al. SDF-1 gene polymorphisms and syncytia induction in Brazilian HIV-1 infected individuals. Microb Pathog. 2003;35:31–4.

    Article  PubMed  CAS  Google Scholar 

  16. Winkler C, Modi W, Smith MW, et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science. 1998;118:681–8.

    Google Scholar 

  17. Kawasaki E, Ide A, Abiru N, et al. Stromal cell-derived factor-1 chemokine gene variant in patients with type 1 diabetes and autoimmune thyroid disease. Ann N Y Acad Sci. 2004;1037:79–83.

    Article  PubMed  CAS  Google Scholar 

  18. Dean M, Carington M, O’Brien SJ. Balanced polymorphism selected by genetic versus infectious human disease. Annu Rev Genomics Hum Genet. 2002;3:263–92.

    Article  PubMed  CAS  Google Scholar 

  19. De Oliveira Cavassin GG, De Lucca FL, Delgado Andre N, et al. Molecular investigation of the stromal cell-derived factor-1 chemokine in lymphoid leukemia and lymphoma patients from Brazil. Blood Cells Mol Dis. 2004;33:90–3.

    Article  PubMed  Google Scholar 

  20. Akekawatchai C, Holland JD, Kochetkova M, Wallace JC, McColl SR. Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem. 2005;280:39701–8.

    Article  PubMed  CAS  Google Scholar 

  21. Cabioglu N, Summy J, Miller C, et al. CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res. 2005;65:6493–7.

    Article  PubMed  CAS  Google Scholar 

  22. Salmaggi A, Maderna E, Calatozzolo C, et al. CXCL12, CXCR4 and CXCR7 expression in brain metastases. Can Biol Ther. 2009;8:1608–14.

    Article  CAS  Google Scholar 

  23. Miao Z, Luker KE, Summers BC, et al. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci U S A. 2007;104:15735–40.

    Article  PubMed  CAS  Google Scholar 

  24. Theodoropoulos GE, Panoussopoulos GS, Michalopoulos NV, et al. Analysis of the stromal cell-derived factor 1-3′A gene polymorphism in pancreatic cancer. Mol Med Report. 2010;3:693–8.

    PubMed  CAS  Google Scholar 

  25. Hirata H, Hinoda Y, Kikuno N, et al. CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. Clin Cancer Res. 2007;13:5056–62.

    Article  PubMed  CAS  Google Scholar 

  26. de Oliveira KB, Guembarovski RL, Oda JM, et al. CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients. Cytokine. 2011;55:260–5.

    Article  PubMed  Google Scholar 

  27. Dimberg J, Hugander A, Löfgren S, Wågsäter D. Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients. Int J Mol Med. 2007;19:11–5.

    PubMed  CAS  Google Scholar 

  28. Hidalgo-Pascual M, Galan JJ, Chaves-Conde M, et al. Analysis of CXCL12 3′UTR G>A polymorphism in colorectal cancer. Oncol Rep. 2007;18:1583–7.

    PubMed  CAS  Google Scholar 

  29. Chang SC, Lin PC, Yang SH, Wang HS, Li AF, Lin JK. SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer. Ann Surg Oncol. 2009;16:2323–30.

    Article  PubMed  Google Scholar 

  30. Schimanski CC, Jordan M, Schlaegel F, et al. SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer. Int J Oncol. 2011;39:515–20.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank those breast cancer patients and normal individuals for their kind participation in this project. This work was funded by a grant from Shiraz University of Medical Sciences [grant no. 87-4218] and by Shiraz Institute for Cancer Research [ICR-87-133].

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Shiraz Institute for Cancer Research, Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, PO Box: 71345, 1798, Shiraz, Iran

    Mahboobeh Razmkhah & Abbas Ghaderi

Authors
  1. Mahboobeh Razmkhah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abbas Ghaderi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abbas Ghaderi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Razmkhah, M., Ghaderi, A. SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers. Indian J Gastroenterol 32, 28–31 (2013). https://doi.org/10.1007/s12664-012-0283-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12664-012-0283-0

Keywords

Search

Navigation