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Prognostic Utility of Fatty Acid-Binding Protein 4 in Patients with Type 2 Diabetes and Acute Ischemic Stroke

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Abstract

The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum fatty acid-binding protein 4 (FABP4) could be a prognostic factor in Chinese patients with type 2 diabetes (T2DM) and acute ischemic stroke (AIS). From September 2015 to August 2016, consecutive first-ever AIS patients combined with T2DM were included in this study. FABP4, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcomes within 3 months. Multivariate analyses were performed using logistic regression models. We measured FABP4 in 329 patients. The median age of patients included in this study was 63 (IQR, 56–72) years and 45.9% were women. FABP4 serum levels were obtained at a median of 8.5 h (IQR, 4.0–14.0 h) after the stroke onset with a median value of 21.4 ng/ml (IQR, 15.6–28.2 ng/ml). In multivariable models, FABP4 remained an independent stroke severity predictor with an adjusted OR of 1.05 (95% CI, 1.02–1.09). In multivariate models comparing the third (odd ratio (OR), 2.25; 95% confidence interval (CI), 1.59–3.54) and fourth quartiles (OR, 3.75; 95% CI, 2.48–5.03) against the first quartile of the FABP4, levels of FABP4 were associated with poor functional outcome. At 3 months, 38 patients (11.6%; 95%CI, 8.1–15.0%) had died. The mortality distribution across the FABP4 quartiles ranged between 3.7% (first quartile) and 20.7% (fourth quartile). Elevation of FABP4 is associated with an increased risk of death and poor functional outcome events in patients with type 2 diabetes and acute ischemic stroke and is independent of other established clinical risk predictors and biomarkers.

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Acknowledgments

We are grateful to the Department of Neurology and Emergency; the nurses, physicians, and patients who participated in our study; and the staff of the central laboratory of the Hospital. Authors also acknowledge the contribution of the editors and reviewers who have helped us to improve the manuscript.

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

This study was supported by grants from the Scientific research project of health and Family Planning Commission of Heilongjiang province (No. 2017–337), Graduate Innovative Project of Heilongjiang province (No. 2016YJSCX-20MY), and Scientific research project of Mudanjiang science and Technology Bureau (No. Z2016s0066).

Role of the Sponsor

The funding organizations had no role in the design and concept of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.

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Authors and Affiliations

  1. Department of Endocrinology, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China

    Siou Li, Yifei Lian & Haifu Zhu

  2. Department of Neurology, Hongqi Hospital of Mudanjiang Medical University, No 5, Tongxiang Road, Aimin District, Mudanjiang, 157011, People’s Republic of China

    Pengxiang Bi, Weina Zhao, Dan Xu, Jiayuan Ding, Quankui Wang & Changhao Yin

Authors
  1. Siou Li
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  2. Pengxiang Bi
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  3. Weina Zhao
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  4. Yifei Lian
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  5. Haifu Zhu
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  6. Dan Xu
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  7. Jiayuan Ding
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  8. Quankui Wang
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  9. Changhao Yin
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Contributions

Yin had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Li, Bi, Zhao, Lian, Zhu, Xu, Ding, Wang, Yin.

Acquisition of data: Li, Bi, Zhao, Lian, Yin.

Analysis and interpretation of data: Li, Zhu, Xu, Ding, Wang, Yin.

Drafting of the manuscript: Li, Bi, Zhao, Lian, Yin.

Critical revision of the manuscript for important intellectual content: Zhu, Xu, Ding, Wang.

Administrative, technical, or material support: Li, Bi, Zhao, Lian, Zhu, Xu, Ding, Wang, Yin.

Obtain funding: Yin.

Study supervision: Yin.

Corresponding author

Correspondence to Changhao Yin.

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Li, S., Bi, P., Zhao, W. et al. Prognostic Utility of Fatty Acid-Binding Protein 4 in Patients with Type 2 Diabetes and Acute Ischemic Stroke. Neurotox Res 33, 309–315 (2018). https://doi.org/10.1007/s12640-017-9792-z

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  • DOI: https://doi.org/10.1007/s12640-017-9792-z

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