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G protein-coupled receptors in cardiac biology: old and new receptors

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Abstract

G protein-coupled receptors (GPCRs) are seven-transmembrane-spanning proteins that mediate cellular and physiological responses. They are critical for cardiovascular function and are targeted for the treatment of hypertension and heart failure. Nevertheless, current therapies only target a small fraction of the cardiac GPCR repertoire, indicating that there are many opportunities to investigate unappreciated aspects of heart biology. Here, we offer an update on the contemporary view of GPCRs and the complexities of their signalling, and review the roles of the ‘classical’ GPCRs in cardiovascular physiology and disease. We then provide insights into other GPCRs that have been less extensively studied in the heart, including orphan, odorant and taste receptors. We contend that these novel cardiac GPCRs contribute to heart function in health and disease and thereby offer exciting opportunities to therapeutically modulate heart function.

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Notes

  1. A large proportion of this groundbreaking work was recognised with the awarding of the 2012 Nobel Prize for chemistry to Drs. R.J. Lefkowitz and B. Kobilka.

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Acknowledgements

We would also like to thank Dr Jason Peart for valuable comments on the manuscript.

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Funding

This work was supported by grants awarded to WGT from the Australian National Health and Medical Research Council (NHMRC) (1024726) and the National Heart Foundation of Australia (G-12B-6532). SRF was supported by an Australian Postgraduate Award scholarship.

Conflict of interest

Thomas G. Walter, Simon R. Foster, and Roura Eugeni declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia

    Simon R. Foster, Eugeni Roura & Walter G. Thomas

  2. Centre for Nutrition & Food Sciences, Queensland Alliance for Agriculture and Food Innovation, University of Queensland, St Lucia Campus, Brisbane, Australia

    Eugeni Roura

  3. Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, St Lucia Campus, Brisbane, Australia

    Peter Molenaar

  4. School of Medicine, University of Queensland, St Lucia Campus, Brisbane, Australia

    Peter Molenaar

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  1. Simon R. Foster
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  2. Eugeni Roura
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Correspondence to Walter G. Thomas.

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Special Issue: Biophysics of Human Heart Failure

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Foster, S.R., Roura, E., Molenaar, P. et al. G protein-coupled receptors in cardiac biology: old and new receptors. Biophys Rev 7, 77–89 (2015). https://doi.org/10.1007/s12551-014-0154-2

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