Skip to main content
Log in

Urinary tract infections in neonates with jaundice in their first two weeks of life

  • Original Article
  • Published:
World Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Background

Hyperbilirubinemia is a frequently seen condition in neonates. This study was undertaken to determine the role of urinary tract infections (UTIs) in the etiology of indirect hyperbilirubinemia in neonates with jaundice in their first two weeks of life.

Methods

The study was conducted prospectively. The subjects were neonates aged 4–14 days with hyperbilirubinemia which could not be detected by routine tests and was sufficiently severe to necessitate phototherapy.

Results

The study was performed in 104 neonates, of whom 18% (n=19) had UTI. The most frequently identified micro-organism was Escherichia coli (43%). Phototherapy duration and rebound bilirubin level were higher in neonates with UTI (P<0.05).

Conclusion

UTI should be investigated in neonates with hyperbilirubinemia of unknown etiology in the first two weeks of life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Pashapour N, Nikibahksh AA, Golmohammadlou S. Urinary tract infection in term neonates with prolonged jaundice. Urol J 2007;4:91–94.

    PubMed  Google Scholar 

  2. Ghaemi S, Fesharaki RJ, Kelishadi R. Late onset jaundice and urinary tract infection in neonates. Indian J Pediatr 2007;74:139–141.

    Article  PubMed  Google Scholar 

  3. Garcia FJ, Nager AL. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics 2002;109:846–851.

    Article  PubMed  Google Scholar 

  4. Bilgen H, Ozek E, Unver T, Biyikli N, Alpay H, Cebeci D. Urinary tract infection and hyperbilirubinemia. Turk J Pediatr 2006;48:51–55.

    PubMed  Google Scholar 

  5. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297–316.

    Article  Google Scholar 

  6. American Academy of Pediatrics, Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia. Practice parameter: management of hyperbilirubinemia in the healthy term newborn. Pediatrics 1994;94:558–565.

    Google Scholar 

  7. Lau AS, Uba A, Lehman D, Geertsma F, Supattapone S. Infectious disease: Urinary tract infections: dysuria and fever. In: Rudolph AM, Kamei RK, eds. Rudolph’s Fundamentals of Pediatrics, 2nd ed. Connecticut: Appleton and Lange, 1998: 301–303.

    Google Scholar 

  8. Nickavar A, Sotoudeh K. Treatment and prophylaxis in pediatric urinary tract infection. Int J Prev Med 2011;2:4–9.

    PubMed Central  PubMed  Google Scholar 

  9. Olusanya O, Owa JA, Olusanya OI. The prevalence of bacteriuria among high risk neonates in Nigeria. Acta Paediatr Scand 1989;78:94–99.

    Article  CAS  PubMed  Google Scholar 

  10. Maisels MJ, Newman TB. Neonatal Jaundice and Urinary Tract Infections. Pediatrics 2003;112:1213–1214.

    Article  CAS  PubMed  Google Scholar 

  11. Sarýcý SÜ, Kul M, Alpay F. Neonatal Jaundice Coinciding With or Resulting From Urinary Tract Infections? Pediatrics 2003;112:1212–1213.

    Article  Google Scholar 

  12. Xinias I, Demertzidou V, Mavroudi A, Kollios K, Kardaras P, Papachristou F, et al. Bilirubin levels predict renal cortical changes in jaundiced neonates with urinary tract infection. World J Pediatr 2009;5:42–45.

    Article  CAS  PubMed  Google Scholar 

  13. Chavalitdhamrong PO, Escobedo MB, Barton LL, Zarkowsky H, Marshall RE. Hyperbilirubinaemia and bacterial infection in the newborn. A prospective study. Arch Dis Child 1975;50:652–654.

    Article  CAS  Google Scholar 

  14. Wong RJ, Desandre GH, Sibley E, Stevenson DK. Neonatal Jaundice and Liver Disease. In: Martin R J, Fanoroff AA, Walsh MC, eds. Fanaroff and Martin’s Neonatal-Peinatal Medicine Diseases of the Fetus and Infant, 8th ed. Philadelphia: Mosby Elsevier, 2006: 1419–1465.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mehmet Mutlu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mutlu, M., Çayır, Y. & Aslan, Y. Urinary tract infections in neonates with jaundice in their first two weeks of life. World J Pediatr 10, 164–167 (2014). https://doi.org/10.1007/s12519-013-0433-1

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12519-013-0433-1

Key words

Navigation