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Assessing Myocardial Disease Using T1ρ MRI

  • Molecular Imaging (G Strijkers, Section Editor)
  • Published:
Current Cardiovascular Imaging Reports Aims and scope Submit manuscript

Abstract

There is great interest to use magnetic resonance imaging (MRI) for non-invasive assessment of myocardial disease in ischemic and non-ischemic cardiomyopathies. Recently, there has been a renewed interest to use a magnetic resonance imaging (MRI) technique utilizing spin locking radiofrequency (RF) pulses, called T1ρ MRI. The spin locking RF pulse creates sensitivity to some mechanisms of nuclear relaxation such as 1H exchange between water and amide, amine and hydroxyl functional groups in molecules; consequently, there is the potential to non-invasively, and without exogenous contrast agents, obtain important molecular information from diseased myocardial tissue. The purpose of this article is to review and critically examine the recent published literature in the field related to T1ρ MRI of myocardial disease.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgements

The authors thank Dr. Ravinder Reddy for reviewing this work and providing valuable insight and expertise.

Conflict of Interest

Yuchi Han, Timo Liimatainen, Robert C Gorman, Walter RT Witschey declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Blvd, Bldg 421, 7th floor, Rm 103, Philadelphia, PA, 19104, USA

    Robert C. Gorman & Walter R. T. Witschey

  2. Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

    Timo Liimatainen

  3. Cardiovascular Division, Department of Medicine, Perelman School of Medicine, Hospital of the University of Pennsylvania, 9022 Gates, 3400 Spruce Street, Philadelphia, PA, USA

    Yuchi Han

Authors
  1. Yuchi Han
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  2. Timo Liimatainen
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  3. Robert C. Gorman
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  4. Walter R. T. Witschey
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Corresponding author

Correspondence to Walter R. T. Witschey.

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Sources of Funding

The authors gratefully acknowledge support from the National Institutes of Health, National Heart Lung and Blood Institute grants K99-HL108157, R01-HL063954, Cardiovascular Medical Research and Education Fund, the Academy of Finland and the Sigrid Juselius Foundation.

This article is part of the Topical Collection on Molecular Imaging

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Han, Y., Liimatainen, T., Gorman, R.C. et al. Assessing Myocardial Disease Using T1ρ MRI. Curr Cardiovasc Imaging Rep 7, 9248 (2014). https://doi.org/10.1007/s12410-013-9248-7

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  • DOI: https://doi.org/10.1007/s12410-013-9248-7

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