Abstract
Primary squamous cell carcinoma is rarely observed, with a reported incidence of 0.04–0.07 % of all gastric cancers. An 81-year-old male underwent chemoradiotherapy for type 1 gastric cancer of the posterior wall of the cardiac region in 2005. The tumor disappeared after 1 year of therapy, following which an area of white epithelium, approximately 30 mm in diameter and continuous with the esophageal mucosa, became visible. Biopsy of the white epithelium indicated normal squamous epithelium. An elevated lesion was subsequently detected in the area of white epithelium on upper gastrointestinal endoscopy during a follow-up examination 5 years after therapy. As a biopsy of the same site indicated squamous cell carcinoma, we performed endoscopic submucosal dissection. Histopathological examination indicated high-grade fibrosis due to radiotherapy and showed a moderately differentiated squamous cell carcinoma invading the scarred portion. We describe a case where the developmental process of a squamous cell carcinoma was observed using endoscopy, including narrow band imaging with magnification. This carcinoma likely originated from squamous metaplasia that developed after chemoradiotherapy was administered for a gastric cancer.
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References
Hoshi K, Hanyu H, Takeshita K, et al. The 40th meeting of Japanese Research Society for Gastric Cancer. Gan Chiryo Gakkai Zasshi. 1983;18:2112–24 (In Japanese).
Straus R, Heschel S, Fortmann DJ. Primary adenosquamous carcinoma of the stomach. A case report and review. Cancer. 1969;24(5):985–95.
Oberling C, Wolf M. Sur un cas d’epithelioma polymorphe (grandularie, epidermoide et myxoid) du pylore. Bul Ass France. Cancer. 1927;16:68.
Singer HA. Leukoplakia of the stomach. Report of a case. Arch Pathol. 1930;9:676–82.
Watson GW, Fkint ER, Stewart MJ. Hyperplastic tuberculosis of the stomach causing hour-glass deformity. With complete squamous metaplasia of the upper loculus. Br J Surg. 1936;24:333–40.
Sailer S. Diffuse metaplastic gastritis in a patient with prolonged cahexia and macrocytic anemia. Arch Pathol. 1943;35:739–43.
Tolia V, Chang C, Emami A. Juvenile onset pernicious anemia, partial intestinal villous atrophy, ulcerative colitis, and squamous metaplasia. Am J Gastroenterol. 1986;81:803–7.
Fujisawa Takashi, Ishihara Akio, Ueyama Shigemitsu. A case report of gastric squamous metaplasia with no evidence of malignancy followed using narrow-band imaging. Gastroenterol Endosc. 2009;51(10):2704–11.
Muto M, Hasebe T, Muro K, et al. Primary squamous cell carcinoma of the stomach:a case report with a review of Japanese and western literature. Hepatogastroenterology. 1999;46:3015–8.
Parks RE. Squamous neoplasms of the stomach. Am J Roentol. 1967;101:447–9.
Vaughan WP, Straus FH, Paloyan D. Squamous carcinoma of the stomach after luetic linitis plastic. Gastroenterology. 1977;72:945–8.
Eaton H, Tennekoon GE. Squamous carcinoma of the stomach following corrosive acid burns. Br J Surg. 1972;59:382–7.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
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Informed consent was obtained from all patients for being included in the study.
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Sakemi, R., So, S., Morimitsu, Y. et al. Endoscopic submucosal dissection of squamous cell carcinoma in the upper stomach 5 years after chemoradiotherapy for adenocarcinoma. Clin J Gastroenterol 7, 310–315 (2014). https://doi.org/10.1007/s12328-014-0503-5
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DOI: https://doi.org/10.1007/s12328-014-0503-5