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Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance

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Abstract

Various evidences have unveiled the significance of Vitamin D in diverse processes which include its action in prevention of immune dysfunction, cancer and cardiometabolic disorders. Studies have confirmed the function of VD in controlling the expression of approximately nine hundred genes including gene expression of insulin. VD insufficiency may be linked with the pathogenesis of diseases that are associated with insulin resistance (IR) including diabetes as well as obesity. Thus, VD lowers IR-related disorders such as inflammation and oxidative stress. This review provides an insight regarding the molecular mechanism manifesting, how insufficiency of VD may be connected with the IR and diabetes. It also discusses the effect of VD in maintaining the Ca2+ levels in beta cells of the pancreas and in the tissues that are responsive to insulin.

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Acknowledgements

The Authors are highly indebted to Director Centre of Research for Development, University of Kashmir for providing the necessary guidance to make the present study possible. The Author namely Najeebul Tarfeen is a recipient of ICMR-JRF (No. 3/1/3/JRF-2019/HRD (LS).

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Authors and Affiliations

  1. Centre of Research for Development, University of Kashmir, Srinagar, India

    Najeebul Tarfeen & Bashir Ahmad Ganai

  2. Department of Environmental Science, University of Kashmir, Srinagar, India

    Khair Ul Nisa

  3. Department of Biochemistry, University of Kashmir, Srinagar, India

    Mir Bilal Ahmad

  4. Multidisciplinary Research Unit (MRU), Government Medical Collage (GMC) Srinagar, Srinagar, J & K, 190010, India

    Ajaz Ahmad Waza

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  1. Najeebul Tarfeen
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  2. Khair Ul Nisa
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  3. Mir Bilal Ahmad
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  4. Ajaz Ahmad Waza
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  5. Bashir Ahmad Ganai
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Contributions

N.T. had written the paper, K.U.N., M.B.A., A.A.W. had helped in editing the paper. B.A.G. gave final shape to the paper.

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Correspondence to Bashir Ahmad Ganai.

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Tarfeen, N., Nisa, K.U., Ahmad, M.B. et al. Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance. Ind J Clin Biochem 38, 407–417 (2023). https://doi.org/10.1007/s12291-022-01105-0

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