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Metabolic Bone Profile of Healthy Adult North Indian Population from Chandigarh Urban Bone Epidemiological Study (CUBES)

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Abstract

We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20–80 years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50 years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5 ng/mL and 14.3 ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = − 0.4, p < 0.0001), and showed an increasing trend with age. We have thus presented metabolic bone profile of healthy, adult north Indian population. These reference values can be used for diagnosis and monitoring of various MBDs. Vitamin D deficiency is still rampant in our population in spite of increasing awareness.

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Authors and Affiliations

  1. Department of Endocrinology, PGIMER, Chandigarh, India

    Anshita Aggarwal, Abhilasha Garg, Rimesh Pal, Anil Bhansali, Priyanka Singh, Naresh Sachdeva & Sanjay Kumar Bhadada

  2. Department of Biochemistry, PGIMER, Chandigarh, India

    Sant Ram & Sadhna Sharma

  3. Department of Community Medicine, PGIMER, Chandigarh, India

    J. S. Thakur

Authors
  1. Anshita Aggarwal
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  2. Sant Ram
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  3. Abhilasha Garg
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  4. Rimesh Pal
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  5. Anil Bhansali
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  6. Priyanka Singh
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  7. Sadhna Sharma
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  8. J. S. Thakur
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  9. Naresh Sachdeva
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  10. Sanjay Kumar Bhadada
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Correspondence to Sanjay Kumar Bhadada.

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Aggarwal, A., Ram, S., Garg, A. et al. Metabolic Bone Profile of Healthy Adult North Indian Population from Chandigarh Urban Bone Epidemiological Study (CUBES). Ind J Clin Biochem 36, 67–73 (2021). https://doi.org/10.1007/s12291-019-00857-6

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  • DOI: https://doi.org/10.1007/s12291-019-00857-6

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