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Relationship Between Hemodynamically Significant Ductus Arteriosus and Ischemia-Modified Albumin in Premature Infants

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Abstract

Hemodynamically significant ductus arteriosus (hsPDA) may alter organ perfusion by interfering blood flow to the tissues. Therefore, in infants with hsPDA, hypoxia occurs in many tissues. In this study, we aimed to investigate the diagnostic significance of serum (ischemia-modified albumin) IMA levels as a screening tool for hsPDA, and its relation to the severity of the disease in the preterm neonates. For this purpose, seventy-two premature infants with gestation age <34 weeks were included in the study. Thirty premature infants with hsPDA were assigned as the study group and 42 premature infants without PDA were determined as the control group. Blood samples were collected before the treatment and 24 h after the treatment, and analyzed for IMA levels. IMA levels in the study group (1.26 ± 0.36 ABSU) were found to be significantly higher than control group (0.65 ± 0.12 ABSU) (p < 0.05). In infants with hsPDA, a positive correlation was found between IMA and PDA diameter (ρ = 0.876, p = 0.022), and LA/Ao ratio (ρ = 0.863, p = 0.014). The cut-off value of IMA for hsPDA was measured as 0.78 ABSU with 88.89 % sensitivity, and 90.24 % specificity, 85.71 % positive predictive, 92.5 % negative predictive value [area under the curve (AUC) = 0.96; p < 0.001]. The mean IMA value of the infants with hsPDA before treatment was 1.26 ± 0.36 ABSU, and the mean IMA value of infants after medical treatment was 0.67 ± 0.27 ABSU (p = 0.03). We concluded that IMA can be used as a marker for the diagnosis and monitoring of a successful treatment of hsPDA.

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Authors and Affiliations

  1. Department of Neonatal Intensive Care Unit, Erzurum District Training and Research Hospital, Erzurum, Turkey

    Hasan Kahveci

  2. Department of Neonatal Intensive Care Unit, Denzili Public Healt Hospital, Ankara, Turkey

    Cüneyt Tayman

  3. Department of Neonatal Intensive Care Unit, Nenehatun Obstetrics and Gynecology Hospital, Erzurum, Turkey

    Fuat Laloğlu, Nazan Kavas & Abdulah Erdil

  4. Department of Pediatric Cardiology, Erzurum District Training and Research Hospital, Erzurum, Turkey

    Murat Ciftel & Osman Yılmaz

  5. Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey

    Esra Laloğlu & Hülya Aksoy

  6. Department of Pediatrıcs, Dr. Sami Ulus Children Research and Training Hospital, Ankara, Turkey

    Salih Aydemir

Authors
  1. Hasan Kahveci
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  2. Cüneyt Tayman
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  3. Fuat Laloğlu
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  4. Nazan Kavas
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  5. Murat Ciftel
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  6. Osman Yılmaz
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  7. Esra Laloğlu
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  8. Abdulah Erdil
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  9. Hülya Aksoy
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  10. Salih Aydemir
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Correspondence to Cüneyt Tayman.

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Hasan Kahveci and Cüneyt Tayman are equally the first authors.

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Kahveci, H., Tayman, C., Laloğlu, F. et al. Relationship Between Hemodynamically Significant Ductus Arteriosus and Ischemia-Modified Albumin in Premature Infants. Ind J Clin Biochem 31, 231–236 (2016). https://doi.org/10.1007/s12291-015-0523-z

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  • DOI: https://doi.org/10.1007/s12291-015-0523-z

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