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Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

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Abstract

The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-α and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-α-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients.

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Acknowledgment

We are indebted to SGPGIMS, Lucknow for financial support.

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Authors and Affiliations

  1. Department of Medical Genetics, SGPGIMS, Lucknow, UP, India

    Tabrez Jafar & Suraksha Agrawal

  2. Department of Biochemistry, CSMMU, Chhatrapati Shahuji Maharaj Medical University (Formerly King George Medical University), Chowk, Lucknow, UP, 226003, India

    Abbas Ali Mahdi

  3. Department of Nephrology, SGPGIMS, Lucknow, UP, India

    Raj Kumar Sharma

  4. Department of Pediatrics, CSMMU, Lucknow, UP, India

    Shally Awasthi

  5. Department of Statistics, Lucknow University, Lucknow, UP, India

    G. G. Agarwal

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  1. Tabrez Jafar
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  2. Suraksha Agrawal
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  3. Abbas Ali Mahdi
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Correspondence to Abbas Ali Mahdi.

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Jafar, T., Agrawal, S., Mahdi, A.A. et al. Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children. Ind J Clin Biochem 26, 296–302 (2011). https://doi.org/10.1007/s12291-011-0126-2

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  • DOI: https://doi.org/10.1007/s12291-011-0126-2

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