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Sex hormone binding globulin in breast cancer

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Abstract

The present study was undertaken to determine the significance of sex hormone binding globulin, the major and specific binding protein for testosterone and estradiol, in breast cancer. Among breast cancer patients, lower serum levels of Sex hormone binding globulin and higher levels of testosterone were observed. Sex hormone binding globulin showed an inverse relationship with testosterone and total cholesterol, and a direct relation with HDL-cholesterol. By the western blot analyses, Sex hormone binding globulin was detected in all biological samples that we examined. In the breast tumor tissue sections, immuno-staining for Sex hormone binding globulin was confined in cell cytoplasm and 29% cases were positive, which showed no association with the investigated prognostic markers of breast cancer such as ER and HER-2/neu over-expression. In this study, decreased circulating levels of Sex hormone binding globulin in breast cancer patients possibly indicate higher bioavailable estrogens.

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Authors and Affiliations

  1. Institute of Cytology and Preventive Oncology, 1-7, Sector-39, Noida, 201 301, India

    Dayalu Naik S L, Suresh Hedau, Anil Kumar Bahadur, Renuka Saha, Sudershan Kaur & Amitabha Ray

  2. Department of Radiotherapy, Maulana Azad Medical College, New Delhi, 110 002, India

    Anil Kumar Bahadur

  3. Department of Preventive and Social Medicine, Maulana Azad Medical College, New Delhi, 110 002, India

    Renuka Saha

  4. The Hormel Institute, University of Minnesota, 801-16th Avenue NE, Austin, MN, 55912, USA

    Amitabha Ray

Authors
  1. Dayalu Naik S L
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  2. Suresh Hedau
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  3. Anil Kumar Bahadur
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  4. Renuka Saha
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  5. Sudershan Kaur
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  6. Amitabha Ray
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Correspondence to Suresh Hedau.

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Naik S L, D., Hedau, S., Bahadur, A.K. et al. Sex hormone binding globulin in breast cancer. Indian J Clin Biochem 23, 250–254 (2008). https://doi.org/10.1007/s12291-008-0056-9

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  • DOI: https://doi.org/10.1007/s12291-008-0056-9

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