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Performance Evaluation of Automated Immunohematology Analyzer IH-500 for Blood Bank Testing

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

The automated immunohematology analyzer IH-500 (Bio-rad, Cressier FR, Switzerland) was developed recently for blood bank tests and this study evaluated performance of IH-500. 200 blood samples for ABO/Rh typing were collected. ABO/Rh typing results measured by IH-500 was compared with conventional manual methods. Antibody screening tests were performed with 100 samples using both IH-500 and the Ortho BioVue System, and results were compared. Antibody identification tests were conducted on 5 samples using both IH-500 and the Ortho BioVue System and results were compared. Crossmatching was performed with both IH-500 and conventional manual tube method using 4 patient serum samples and 10 blood cell donors, and 40 results were compared. Isoagglutinin titer of anti-A and anti-B was determined in 10 samples using both IH-500 and the automated analyzer Ortho AutoVue Innova and concordance rates were obtained. The concordance rates of ABO/Rh typing, antibody screening test, antibody identification test, and crossmatching between comparative manual methods and the IH-500 were all 100%. In the evaluation of isoagglutinin titer, 8 (80.0%) results out of 10 samples (80%) showed results within ± 1 titer between the IH-500 and the AutoVue Innova, which indicates the concordance rates of 80.0%. IH-500 reported results with two titers lower than Ortho AutoVue Innova in two samples. The IH-500 demonstrated good concordance rates and provided reliable results compared to comparative manual methods in the blood bank testing. IH-500 would be useful as a possible replacement for conventionally performed manual methods in blood bank testing.

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Authors and Affiliations

  1. Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Bangujin-sunhwandoro 877, Dong-gu, Ulsan, 44033, Korea

    Sang Hyuk Park, Jaewook Kim, Ji-Hun Lim, Joseph Jeong & Seon-Ho Lee

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  1. Sang Hyuk Park
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  2. Jaewook Kim
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Correspondence to Ji-Hun Lim.

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Park, S.H., Kim, J., Lim, JH. et al. Performance Evaluation of Automated Immunohematology Analyzer IH-500 for Blood Bank Testing. Indian J Hematol Blood Transfus 35, 731–735 (2019). https://doi.org/10.1007/s12288-019-01127-4

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