Abstract
Leukocytosis is well recognised in neonate; mostly it is physiological but the counts rarely exceed 30,000/mm3. Hyperleukocytosis defined as WBC count of more than 100,000 mm3 is rare and imposes a diagnostic challenge and should be investigated for leukaemia, leukocyte adhesion defect and myeloproliferative disorders. We report a classic case to highlight this entity.
References
Sushanth, Avabratha KS, Tauro KJ, Shwethadri GK (2010) Hyperleukocytosis in a neonate: a diagnostic dilemma. Indian J Med Paediatr Oncol 31(3):86–88
Granger JM, Kontoyiannis DP (2009) Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study. Cancer 115(17):3919–3923
Alizadeh P, Rahbarimanesh AA, Bahram MG, Salmasian H (2007) Leukocyte adhesion deficiency type 1 presenting as leukemoid reaction. Indian J Pediatr 74(12):1121–1123
Wirbelauer J, Thomas W, Siauw C, Wössner R, Speer CP (2008) Leukemoid reaction in extremely immature preterm infants. Z Geburtshilfe Neonatol 212(5):165–169
Hsiao R, Omar SA (2005) Outcome of extremely low birth weight infants with leukemoid reaction. Pediatrics 116(1):e43–e51
Zwaan MC, Reinhardt D, Hitzler J, Vyas P (2008) Acute leukemias in children with down syndrome. Pediatric Clin North Am 55:53–70
Ishii E et al (2006) Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. Pediatr Blood Cancer 47(3):234–235
Brown L, Shaw T, Wittlake WA (2005) Does leucocytosis identify bacterial infections in febrile neonates presenting to the emergency department? Emerg Med J 22(4):256–259
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Parvez, Y., Mathew, A.G. Hyperleukocytosis in Newborn: A Diagnosis of Concern. Indian J Hematol Blood Transfus 30 (Suppl 1), 131–132 (2014). https://doi.org/10.1007/s12288-013-0286-8
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DOI: https://doi.org/10.1007/s12288-013-0286-8