Abstract
Pancreatic involvement in acute lymphoblastic leukemia (ALL) is uncommon more so in adults. It can present as obstructive jaundice, pancreatitis or can be asymptomatic. We report here the clinical and imaging features in a 28 years old man with B cell ALL with simultaneous involvement of pancreas and bilateral kidneys. Computed tomography of abdomen showed diffuse infiltration of pancreas by multiple tiny hypodense lesions and multiple hypodense lesions in both kidneys. Although leukemic involvement of pancreas is unusual and our patient was asymptomatic, one should consider the possibility of pancreatic infiltration in a leukemic patient presenting with pancreatic enlargement, cholestatic jaundice or pancreatitis.
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References
Choi EK, Byun JH, Lee SJ et al (2007) Imaging findings of leukemic involvement of the pancreaticobiliary system in adults. AJR 188:1589–1595
Ikawa Y, Saikawa Y, Horisawa T, Kuroda R (2007) Pancreatic and renal involvement in pediatric acute lymphoblastic leukemia/lymphoma. J Clin Oncol 25:451–453
Malbora B, Avci Z, Alioglu B, Tutar NU, Ozbek N (2008) A case with mature B-cell acute lymphoblastic leukemia and pancreatic involvement at the time of diagnosis. J Pediatr Hematol Oncol 30:87–89
Sato A, Imaizumi M, Chikaoka S et al (2004) Acute renal failure due to leukemic cell infiltration followed by relapse at multiple extramedullary sites in a child with acute lymphoblastic leukemia. Leuk Lymphoma 45:825–828
Pui CH (2009) Acute lymphoblastic leukemia: introduction. Semin Hematol 46:1–2
Collado L, Dardanelli E, Sierre S, Moguillansky S, Lipsich J (2011) Asymptomatic leukemic-cell infiltration of the pancreas: US findings. Pediatr Radiol 41:779–780
Daniel SV, Vani DH, Smith AM, Hill QA, Menon KV (2010) Obstructive jaundice due to a pancreatic mass: a rare presentation of acute lymphoblastic leukaemia in an adult. JOP 11:72–74
Rausch DR, Norton KI, Glass RB, Kogan D (2002) Infantile leukemia presenting with cholestasis secondary to massive pancreatic infiltration. Pediatr Radiol 32:360–361
Van Beers B, Lalonde L, Soyer P et al (1993) Dynamic CT in pancreatic lymphoma. J Comput Assist Tomogr 17:94–97
Bach AG, Behrmann C, Holzhausen HJ, Katzer M, Arnold D, Spielmann RP, Surov A (2012) Prevalence and patterns of renal involvement in imaging of malignant lymphoproliferative diseases. Acta Radiol 53:343–348
Erdem E, Kayıran P, Ozcelik G, Ozel A, Yildiz Yildirmak Z (2011) Rare presentation of pediatric acute lymphoblastic leukemia: nephromegaly at time of diagnosis. Indian J Hematol Blood Transfus 27:43–45
Hilmes MA, Dillman JR, Mody RJ, Strouse PJ (2008) Pediatric renal leukemia: spectrum of CT imaging findings. Pediatr Radiol 38:424–430
Knoderer HM, Robarge J, Flockhart DA (2007) Predicting asparaginase-associated pancreatitis. Pediatr Blood Cancer 49:634–639
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Ramanathan, S., Prakash, M. & Khandelwal, N. Concurrent Pancreatic and Renal Leukemic Cell Infiltration. Indian J Hematol Blood Transfus 30 (Suppl 1), 57–59 (2014). https://doi.org/10.1007/s12288-013-0246-3
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DOI: https://doi.org/10.1007/s12288-013-0246-3