Abstract
Transfusion Transmitted Infection (TTI) continue to be a problem in many parts of world and multi-transfused patients of beta thalassaemia major are at a particularly increased risk of TTI. This study is aimed to estimate the prevalence of blood TTI in multiple blood transfused patients of beta thalassaemia major. Cross-sectional study of 200 multi-transfused patients of beta thalassaemia major, who were interviewed using a structured questionnaire and history was taken regarding sero-status of HIV (Human Immunodeficiency Virus), HBV (Hepatitis B Virus), HCV (Hepatitis C Virus) infection from their case papers. This study was conducted at the department of Pathology, M.P. Shah medical college, Jamnagar and Thalassemia ward, G.G. Hospital, Jamnagar (Gujarat, India) from March to May 2010. Out of 200 multiple blood transfused patients 7% patients were infected with TTI. Total 9 male patients and 5 female patients were infected with TTI. The seroreactivity for HIV was 3% (06/200); 1% (02/200) were males and 2% (04/200) were females. The seroreactivity for HBV was 2% (04/200) all were males. The seroreactivity for HCV was 2% (04/200); 1.5% (03/200) were males and 0.5% (01/200) was female. HIV, HBV, HCV infections are most prevalent TTI among multiple blood transfused patients of beta thalassemia major, and remains a major health problem for these patients.
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References
Bhasin R, Chatterjee K, Ramalingam V (2003) Blood transfusion transmitted diseases. In: Saran R (ed) Transfusion medicine-technical manual, 2nd edn. Director General, Directorate General of Health Services, New Delhi, India, pp 143–174
Pignatti C, Galanello R (2009) Thalassaemias and related disorders: quantitative disorders of hemoglobin synthesis. In: John P (ed) Wintrobe’s clinical hematology, 12th edn. Lippincott Williams & Willkins, Philadelphia, pp 1083–1131
George P, Gert F, Johana E, Spiridoula P, Roumeliotou A (1978) Prevalence of hepatitis A and B infections in multiply transfused thalassaemic patients. Br Med J 1:689–691
Daniele P, Carmen C, Paolo R, Fulvio M, Patrizia B, Claudia M, Girolamo S (1998) The current risk of retroviral infections transmitted by transfusion in patients who have undergone multiple transfusions. Arch Intern Med 158:1566–1569
Banerjee D, Chandra S, Bhattacharya D (1990) HBV & HIV seropositivity in multi-transfused hemophilics & thalassaemics in eastern India. Indian J Med Res 91:63–66
Choudhary N, Saraswat S, Naveed M (1998) Serological monitoring of thalassaemia major patients for transfusion associated viral infections. Indian J Med Res 107:262–268
Mollah A, Nahar N, Siddique M, Anwer K, Tariq H, Md. Golam A (2003) Common trasfusion-transmitted infectious agents among thalassaemic children in Bangladesh. J Health Popul Nutr 21:67–71
Sheyyab M, Batieha A, Khateeb M (2001) The prevalence of hepatitis B, hepatitis C and human immune deficiency virus markers in multi-transfused patients. J Trop Pediatrics 47:239–242
Hussain H, Iqbal R, Khan H, Burki F, Sethi J, Hussan M, Nisar Y, Jai K (2008) Prevalence of hepatitis C in beta thalassaemia major. Gomal J Med Sci 6:87–90
Singh H, Pradhan M, Singh R, Phadke S, Naik S, Aggarwal R, Naik S (2003) High frequency of hepatitis B virus infection in patients with beta thalassaemia receiving multiple transfusions. Vox Sang 84:292–299
Ikram N, Lubna N, Zaheer H, Khan M (2004) Hepatitis C virus seropositivity in repeatedly transfused thalassaemia major patients. Int J Pathol 2:20–23
Shekhar H, Kabir Y, Mosharaf H, Mesbah U, Hossain S, Shahjalal H (2007) Blood transfusion-mediated viral infections in thalassemic children in Bangladesh. J Med Sci 7:131–135
Erich V, Goncales NS, Serge X, Marcelo A, Angerami RN, Monica P (2005) Transfusion transmitted infections among multi-transfused patients in Brazil. J Clin Viro 34:S27–S32
Lopez L, Lopez P, Antonio A, Ismael R, Lopez J, Edgar L, Juan I, Bentancor N (2005) Risk factors for hepatitis B and C in multi transfused patients in Uruguay. J Clin Viro 34:S69–S74
Kapoor C, Muhammad H, Muhammad I (2007) Poly transfused thalassaemia patients; prevalence of viral markers and malaria parasite. Prof Med J 14:177–181
Ocak S, Hasan K, Meryem C, Edip G, Ozturk M (2006) Seroprevalence of hepatitis B and hepatitis C in patients with thalassaemia and sickle cell anaemia in a long term follow-up. Arch Med Res 37:895–898
Zurlo M, Stefano P, Pignatti B, Palma A, Melevendi C, Gregorio F, Burattini M, Terzoli S (1989) Survival and causes of death in thalassaemia major. Lancet 2:27–30
Bonkovsky H, Banner B, Rothman A (1997) Iron and chronic viral hepatitis. Hepatology 25:759–768
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Vidja, P.J., Vachhani, J.H., Sheikh, S.S. et al. Blood Transfusion Transmitted Infections in Multiple Blood Transfused Patients of Beta Thalassaemia. Indian J Hematol Blood Transfus 27, 65–69 (2011). https://doi.org/10.1007/s12288-011-0057-3
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DOI: https://doi.org/10.1007/s12288-011-0057-3