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The Role of Genetics in Host Responses to Mucosal and Invasive Candidiasis

  • Genomics and Pathogenesis (Shmuel Shoham, Section Editor)
  • Published:
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Abstract

The development of mucosal and invasive candidiasis depends upon a variety of innate and acquired risk factors. The number of genes known to be important for immunity against candidiasis has been increasing. Studies of variants of these genes are facilitating our knowledge of host predisposition to infection. Insights gleaned from genetic variants identified in patients with primary immunodeficiency syndromes such as chronic mucocutaneous candidiasis have further aided in this process. This article reviews data from genomic association studies in patients with such syndromes and in broader patient populations. These studies are placed within the framework of our current understanding of antifungal host defenses.

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Disclosure

Conflicts of Interest: S. Shoham: honoraria from AdvanDx and travel reimbursement from Merck; S. Dufresne: none.

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  1. Transplant and Oncology ID Program, Johns Hopkins University School of Medicine, 1830 E. Monument St., Room 450-D, Baltimore, MD, 21205, USA

    Shmuel Shoham & Simon F. Dufresne

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  2. Simon F. Dufresne
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Correspondence to Shmuel Shoham.

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Shoham, S., Dufresne, S.F. The Role of Genetics in Host Responses to Mucosal and Invasive Candidiasis. Curr Fungal Infect Rep 5, 262–268 (2011). https://doi.org/10.1007/s12281-011-0065-7

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