Skip to main content
Log in

Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats

  • Note
  • Published:
The Journal of Microbiology Aims and scope Submit manuscript

Abstract

We investigated the weight-gain suppressive effect of Lactobacillus gasseri BNR17 isolated from human breast milk. Rats were fed a high-carbohydrate diet and administered BNR17 (BNR17 group) twice daily for twelve weeks. Changes were observed in body weight and white adipose tissue mass. The percent increase in body weight (P=0.0331) and fat pad mass (P<0.01) was significantly lower in the BNR17 group, and the FER was moderately lower (P=0.0769). These data suggest that BNR17 can prevent diet-induced overweight and may become an alternative method for treating weight problems and obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Altunkaynak, B.Z. and E. Ozbek. 2009. Overweight and structural alterations of the liver in female rats fed a high-fat diet: a stereological and histological study. Turk. J. Gastroenterol. 20, 93–103.

    PubMed  Google Scholar 

  • Bhathena, J., C. Martoni, A. Kulamarva, A.M. Urbanska, M. Malhotra, and S. Prakash. 2009. Orally delivered microencapsulated live probiotic formulation lowers serum lipids in hypercholesterolemic hamsters. J. Med. Food 12, 310–319.

    Article  CAS  PubMed  Google Scholar 

  • Cusi, K. 2010. The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr. Diab. Rep. 10, 306–315.

    Article  CAS  PubMed  Google Scholar 

  • Delzenne, N. and G. Reid. 2009. No causal link between obesity and probiotics. Nat. Rev. Microbiol. 7, 901; author reply 901.

    Article  CAS  PubMed  Google Scholar 

  • Ehrlich, S.D. 2009. Probiotics-little evidence for a link to obesity. Nat. Rev. Microbiol. 7, 901; author reply 901.

    Article  CAS  PubMed  Google Scholar 

  • Guandalini, S. 2008. Probiotics for children with diarrhea: an update. J. Clin. Gastroenterol. 42, S53–S57.

    Article  PubMed  Google Scholar 

  • Isolauri, E. and S. Salminen. 2008. Probiotics: use in allergic disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) research group report. J. Clin. Gastroenterol. 42, S91–S96.

    Article  PubMed  Google Scholar 

  • Kumar, M., A. Kumar, R. Nagpal, D. Mohania, P. Behare, V. Verma, P. Kumar, D. Poddar, P.K. Aggarwal, C.J. Henry, S. Jain, and H. Yadav. 2010. Cancer-preventing attributes of probiotics: an update. Int. J. Food Sci. Nutr. 61, 473–496.

    Article  CAS  PubMed  Google Scholar 

  • Lee, K., K. Paek, H.Y. Lee, J.H. Park, and Y. Lee. 2007. Antiobesity effect of trans-10, cis-12 conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice. J. Appl. Microbiol. 103, 1140–1146.

    Article  CAS  PubMed  Google Scholar 

  • Ley, R.E., F. Bäckhed, P. Turnbaugh, C.A. Lozupone, R.D. Knight, and J.I. Gordon. 2005. Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. USA 102, 11070–11075.

    Article  CAS  PubMed  Google Scholar 

  • Ley, R.E., P.J. Turnbaugh, S. Klein, and J.I. Gordon. 2006. Human gut microbes associated with obesity. Nature 444, 1022–1023.

    Article  CAS  PubMed  Google Scholar 

  • Lye, H.S., C.Y. Kuan, J.A. Ewe, W.Y. Fung, and M.T. Liong. 2009. The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. Int. J. Mol. Sci. 10, 3755–3775.

    Article  CAS  PubMed  Google Scholar 

  • Mennigen, R. and M. Bruewer. 2009. Effect of probiotics on intestinal barrier function. Ann. NY. Acad. Sci. 1165, 183–189.

    Article  PubMed  Google Scholar 

  • Nguyen, T.D., J.H. Kang, and M.S. Lee. 2007. Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects. Int. J. Food Microbiol. 113, 358–361.

    Article  CAS  PubMed  Google Scholar 

  • Olivares, M., M.A. Díaz-Ropero, N. Gómez, F. Lara-Villoslada, S. Sierra, J.A. Maldonado, R. Martín, E. López-Huertas, J.M. Rodríguez, and J. Xaus. 2005. Oral administration of two probiotic strains, Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711, enhances the intestinal function of healthy adults. Int. J. Food Microbiol. 107, 104–111.

    Article  PubMed  Google Scholar 

  • Owen, C.G., R.M. Martin, P.H. Whincup, G.D. Smith, and D.G. Cook. 2006. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am. J. Clin. Nutr. 84, 1043–1054.

    CAS  PubMed  Google Scholar 

  • Owen, C.G., R.M. Martin, P.H. Whincup, G.D. Smith, and M.W. Gillman. 2008. The effect of breastfeeding on mean body mass index throughout life: a quantitive review of published and unpublished observational evidence. Am. J. Clin. Nutr. 82, 1298–1307.

    Google Scholar 

  • Perdigón, G., R. Fuller, and R. Raya. 2001. Lactic acid bacteria and their effect on the immune system. Curr. Issues Intest. Microbiol. 2, 27–42.

    PubMed  Google Scholar 

  • Raoult, D. 2009. Probiotics and obesity: a link? Nat. Rev. Microbiol. 7, 616.

    Article  CAS  Google Scholar 

  • Turnbaugh, P.J., R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031.

    Article  PubMed  Google Scholar 

  • Yun, S.I., H.O. Park, and J.H. Kang. 2009. Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes. J. Appl. Microbiol. 107, 1681–1686.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Han-Oh Park.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kang, JH., Yun, SI. & Park, HO. Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats. J Microbiol. 48, 712–714 (2010). https://doi.org/10.1007/s12275-010-0363-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12275-010-0363-8

Keywords

Navigation