Abstract
Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory marine species worldwide and is typically found in various types of substrates in tropical and subtropical marine environments including sediments and marine organisms. This genus produces a wide range of chemical scaffolds and bioactive compounds such as lomaiviticins, cyclomarins, rifamycins, salinaphthoquinones, and salinosporamides. This review arranged Salinispora derived secondary metabolites according to the three species that comprise the genus. Moreover, muta- and semi-synthesis analogs derived from salinosporamide were also described in this review.
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Acknowledgements
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT under Grant Nos. NRF-2019R1F1A1059033 (to I.Y.) and 2017R1D1A1B03028172 (to S.-J.N.).
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Kim, H., Kim, S., Kim, M. et al. Bioactive natural products from the genus Salinospora: a review. Arch. Pharm. Res. 43, 1230–1258 (2020). https://doi.org/10.1007/s12272-020-01288-1
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DOI: https://doi.org/10.1007/s12272-020-01288-1