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Rab25 and RCP in cancer progression

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Abstract

Cancer invasion and metastasis is the crucial cause of death for most cancer patients. Endosome recycling of receptors for growth factors and adhesion molecules to the plasma membrane prevents them from degradation at the inside of the lysosome and recapitulates their functions, leading to major causativeness of cancer progression. Rab25 belongs to Rab-GTPase family and implicated in cancer progression in a context-dependent manner. Identified as a binding partner of Rab25, Rab coupling protein (RCP) augments cancer invasion and metastasis. In the present review, we document recent progress in Rab25- and RCP-induced cancer progression. In addition, we raise several questions should be answered for better understanding how endosome recycling by Rab25 and RCP influences cancer progression. Lastly, we update the potential therapeutic armaments to regulate Rab protein-induced endosome recycling for this deadly disease.

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Abbreviations

RCP:

Rab coupling protein

RTK:

Receptor tyrosine kinase

EGFR:

Epidermal growth factor receptor

TGF:

Transforming growth factor

PI3 K:

Phosphoinositide 3-kinase

GEF:

Guanine nucleotide exchange factor

GAP:

GTPase-activating protein

EMT:

Epithelial mesenchymal transition

DNMTs:

DNA methyltransferases

SIRT1:

Sirtuin 1

TNBC:

Triple-negative breast cancer

VEGF:

Vascular endothelial growth factor

CLIC3:

Intracellular channel protein 3

CLIC3:

Chloride intracellular channel protein 3

Rab11-FIP1:

Rab11 family of interacting proteins

RBD:

Rab binding domain

NSCLC:

Non-small cell lung carcinoma

ER:

Estrogen receptor

PA:

Phosphatidic acid

DGK-α:

Diacylglycerol kinase alpha

GOF:

Gain-of-function

MET:

Mesenchymal–epithelial transition

WIP:

WASP-interacting protein

YAP:

Yes-associated protein

RabGGTase:

Rab geranylgeranyl transferase

siRNAs:

Small interfering RNAs

miRNA:

microRNAs

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Acknowledgements

This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology [NRF-2017R1E1A1A01074091, 2017R1A2B4007361].

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  1. Department of Pharmacology, College of Medicine, Konyang University, 821 Medical Science Building, 158 Gwanjeodong-ro, Seo-gu, Daejeon, 35365, Republic of Korea

    Kyung Hwa Cho & Hoi Young Lee

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Cho, K.H., Lee, H.Y. Rab25 and RCP in cancer progression. Arch. Pharm. Res. 42, 101–112 (2019). https://doi.org/10.1007/s12272-019-01129-w

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