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Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

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Abstract

A new alkenylphenol, bavinol A (1), together with six known compounds (2–7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1–7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

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Acknowledgments

This study was financially supported by the National Foundation for Science and Technology Development, Vietnam (Project No: 104.01-2010-16), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (BK21 Plus program; 22A20130000073).

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Authors and Affiliations

  1. Centre of Pharmaceutical Research–Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam

    Hoang Viet Dung & Nguyen Minh Chinh

  2. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, 712-702, Korea

    To Dao Cuong, Mi Hee Woo & Byung Sun Min

  3. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

    To Dao Cuong

  4. Department of Pharmacognosy, Hanoi University of Pharmacy, 15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam

    Do Quyen

  5. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, Korea

    Jeong Ah Kim

  6. Faculty of Food Science and Biotechnology, Pukyung National University, Busan, 608-737, Korea

    Jeong Su Byeon & Jae Sui Choi

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  1. Hoang Viet Dung
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  2. To Dao Cuong
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  3. Nguyen Minh Chinh
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  4. Do Quyen
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  6. Jeong Su Byeon
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  7. Mi Hee Woo
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  8. Jae Sui Choi
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  9. Byung Sun Min
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Correspondence to Byung Sun Min.

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Hoang Viet Dung and To Dao Cuong have contributed equally to this work.

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Dung, H.V., Cuong, T.D., Chinh, N.M. et al. Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity. Arch. Pharm. Res. 38, 677–682 (2015). https://doi.org/10.1007/s12272-014-0432-3

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  • DOI: https://doi.org/10.1007/s12272-014-0432-3

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