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Antibacterial activities of macrolactin a and 7-O-succinyl macrolactin a from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus

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Abstract

The principal objective of this study was to evaluate the antibacterial activities of macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA) generated from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci (VREs) and methicillin-resistant Staphylococcus aureus. The minimal inhibitory concentrations (MICs) of MA and SMA against VREs were 16 and 2∼1 μg/mL, respectively, and the MICs of MA and SMA against methicillin-resistant Staphylococcus aureus were 2 and < 0.25 μg/mL, respectively. Their MIC values were comparable or superior to those of teicoplanin. In evaluating the inhibitory effects of intestinal VRE colonization in mice, the oral MA and SMA effected a rapid inhibition of intestinal VRE colonization in mice, and the intraperitoneal SMA also inhibited VRE colonization, whereas intraperitoneal MA did not.

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Authors and Affiliations

  1. Research and Development Center, Daewoo Pharm. Co. Ltd., Gimhae, 621-749, Korea

    Dong Hee Kim

  2. Clinical Trial Center For Functional Foods, Chonbuk National University Hospital, Jeonju, 561-712, Korea

    Hye Kyung Kim

  3. Department of Smart Foods and Drugs, Inje University, Gimhae, 621-749, Korea

    Kang Min Kim & Chun Kyu Kim

  4. Dong-A University Medical Science Research Center, Busan, 602-714, Korea

    Min Ho Jeong

  5. College of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea

    Chan Young Ko

  6. Department of Pharmacy, Kyungsung University, Busan, 608-736, Korea

    Kyung Ho Moon & Jae Seon Kang

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  1. Dong Hee Kim
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  2. Hye Kyung Kim
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  3. Kang Min Kim
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  4. Chun Kyu Kim
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  5. Min Ho Jeong
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  7. Kyung Ho Moon
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  8. Jae Seon Kang
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Correspondence to Jae Seon Kang.

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Kim, D.H., Kim, H.K., Kim, K.M. et al. Antibacterial activities of macrolactin a and 7-O-succinyl macrolactin a from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus . Arch. Pharm. Res. 34, 147–152 (2011). https://doi.org/10.1007/s12272-011-0117-0

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  • DOI: https://doi.org/10.1007/s12272-011-0117-0

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