Abstract
G-protein coupled receptors (GPCRs) are involved in many physiological and pathophysiological roles. Many important drugs act on GPCRs, either by blocking them (antagonists) or by mimicking the natural ligand (agonists). As GPCRs have been shown to internalize a new concept is currently investigated: application of agonistic ligands fused to drugs to allow selective uptake into specific cells. This has been proven for selective uptake into tumour cells but may be expanded to other systems that selectively express GPCRs.
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Stefanie Babilon Jahrgang 1985. Biochemiestudium (B. Sc./M. Sc.) an der Universität Leipzig. Forschungsaufenthalt bei Prof. Dr. V. Gurevich, Vanderbilt University, Nashville, TN, USA. Seit 2010 Promotionsstudentin bei Prof. Dr. A. G. Beck-Sickinger.
Kerstin Burkert Jahrgang 1987. Biochemiestudium (B. Sc./M. Sc.) an den Universitäten Halle-Wittenberg und Leipzig. Seit 2012 Promotionsstudentin bei Prof. Dr. A. G. Beck-Sickinger.
Verena Ahrens Jahrgang 1985. Biochemiestudium (Diplom) an den Universitäten Potsdam und Leipzig, 2009 Diplom. Promotionsstudentin bei Prof. Dr. A. G. Beck-Sickinger.
Annette G. Beck-Sickinger Jahrgang 1960. Studium der Chemie (Diplom 1986) und Biologie (Diplom 1990) an der Universität Tübingen. 1989 Promotion bei Prof. Dr. G. Jung, Universität Tübingen. Forschungsaufenthalte in La Jolla/Scripps Research Institute, CA, USA und Kopenhagen, Dänemark. 1997–1999 Assistenzprofessorin für Pharmazeutische Biochemie an der ETH Zürich, Schweiz. Seit 1999 Professorin für Biochemie und Bioorganische Chemie am Institut für Biochemie, Universität Leipzig. 2009 Gastprofessorin an der Vanderbilt University, Nashville, TN, USA.
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Burkert, K., Babilon, S., Ahrens, V. et al. Spezifischer Wirkstoff transport durch Rezeptorinternalisierung. Biospektrum 19, 499–501 (2013). https://doi.org/10.1007/s12268-013-0345-6
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DOI: https://doi.org/10.1007/s12268-013-0345-6