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Fremdstoffmetabolismus und Toxizität von Dioxinen

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  • Dioxinrezeptor
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Abstract

The dioxin receptor is a ligand-activated transcription factor with multiple functions in xenobiotic metabolism, development and dioxin toxicity. The focus here is on its roles in regulating endo- and xenobiotic conjugation by UDP-glucuronosyltransferases, and in dioxin-mediated cancer progression. Dioxins are poorly metabolized leading to sustained receptor activation and deregulation of target genes.

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Literatur

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Authors and Affiliations

  1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität Tübingen, Wilhelmstraße 56, D-72074, Tübingen, Germany

    Karl Walter Bock

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  1. Karl Walter Bock
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Correspondence to Karl Walter Bock.

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Karl Walter Bock Apotheker und Arzt. Promotion zum Dr. med an der Universität Freiburg. 1965–1968 Assistent am Biochemischen Institut der Universität Freiburg. 1968–1970 Stipendiat am Department für Zellbiologie der Rockefeller University, New York, USA. 1970–1977 Assistent am Institut für Toxikologie der Universität Tübingen. 1973 Habilitation für Pharmakologie und Toxikologie an der Universität Tübingen. 1977-1987 Leiter der Abteilung Biochemische Pharmakologie am Zentrum für Pharmakologie und Toxikologie der Universität Göttingen. 1987–2000 Direktor des Instituts für Toxikologie der Universität Tübingen.

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Bock, K.W. Fremdstoffmetabolismus und Toxizität von Dioxinen. Biospektrum 18, 593–595 (2012). https://doi.org/10.1007/s12268-012-0233-5

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  • DOI: https://doi.org/10.1007/s12268-012-0233-5

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