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The Role of ADAM17 in Inflammation-Related Atherosclerosis

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Abstract

Atherosclerosis is a chronic inflammatory disease that poses a huge economic burden due to its extremely poor prognosis. Therefore, it is necessary to explore potential mechanisms to improve the prevention and treatment of atherosclerosis. A disintegrin and metalloprotease 17 (ADAM17) is a cell membrane–bound protein that performs a range of functions through membrane protein shedding and intracellular signaling. ADAM17-mediated inflammation has been identified to be an important contributor to atherosclerosis; however, the specific relationship between its multiple regulatory roles and the pathogenesis of atherosclerosis remains unclear. Here, we reviewed the activation, function, and regulation of ADAM17, described in detail the role of ADAM17-mediated inflammatory damage in atherosclerosis, and discussed several controversial points. We hope that these insights into ADAM17 biology will lead to rational management of atherosclerosis.

Graphical abstract

ADAM17 promotes vascular inflammation in endothelial cells, smooth muscle cells, and macrophages, and regulates the occurrence and development of atherosclerosis.

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Abbreviations

ADAM17:

A disintegrin and metalloprotease 17

CSF-1:

Colony-stimulating factor 1

EC:

Endothelial cell

ECAM:

Endothelial cell adhesion molecules

EGFR:

Epidermal growth factor receptor

EMCN:

Endomucin

ER:

Endoplasmic reticulum

ICAM-1:

Intercellular adhesion molecule-1

IL:

Interleukin

ERK:

Extracellular signal–regulated kinases

IL-6R:

IL-6 receptors

iRhom2:

Inactivated rhomboid protein 2

MAPK:

Mitogen-activated protein kinase

MerTK:

Mer tyrosine kinase

MI:

Myocardial infarction

mTNF-α:

Membrane-bound TNF-α

NSAIDS:

Nonsteroidal anti-inflammatory drugs

PDGFR-β:

Platelet-derived growth factor receptor β

RPTK:

Receptor protein tyrosine kinase

SMCs:

Smooth muscle cells

sgp130:

Soluble gp130

sIL-6R:

Soluble IL-6R

sTNF-α:

Soluble TNF-α

TIMP3:

Tissue inhibitor of metalloproteinase 3

TGF:

Transforming growth factor

TNF-α:

Tumor necrosis factor-α

TNFR:

TNF-α receptor

VCAM-1:

Vascular cell adhesion molecule-1

VSMCs:

Vascular smooth muscle cells

Zn-BR:

Zinc-binding region

CX3CL1:

Fractalkine

MMP:

Matrix metalloproteinases

VEGF:

Vascular endothelial growth factor

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Funding

This research was funded by the Natural Science Foundation of Hunan Province (Nos. 2020JJ4850 and 2021JJ31026). The funder had no role in the writing of the manuscript and in the decision to publish it.

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  1. Bai-Yi Tang and Jin Ge The authors contribute equally.

Authors and Affiliations

  1. Department of Cardiology, Third Xiang-Ya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, China

    Bai-Yi Tang, Jin Ge, Juan Wen & Xiao-Hong Tang

  2. Department of Cardiology, Third Hospital of Changsha, 176 W. Laodong Road, Changsha, 410015, Hunan, China

    Yang Wu

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BYT designed, drafted, and revised the manuscript; JG revised and participated in the drafting of the manuscript; YW participated in the drafting and editing of the manuscript; JW contributed to the manuscript editing and funding; XHT proposed the conception, revised the manuscript, and obtained funding. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Juan Wen or Xiao-Hong Tang.

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Tang, BY., Ge, J., Wu, Y. et al. The Role of ADAM17 in Inflammation-Related Atherosclerosis. J. of Cardiovasc. Trans. Res. 15, 1283–1296 (2022). https://doi.org/10.1007/s12265-022-10275-4

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