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LncRNA HDAC11-AS1 Suppresses Atherosclerosis by Inhibiting HDAC11-Mediated Adropin Histone Deacetylation

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Abstract

LncRNA HDAC11-AS1 (HDAC11-AS1) is the natural antisense transcript of HDAC11, a key enzyme for DNA histone deacetylation. We evaluated the role of HDAC11-AS1 in atherosclerosis. In this research, we found that HDAC11-AS1 ameliorated blood lipid levels and atherosclerosis in high fat-dieted apoE−/− mice by regulating HDAC11 negatively. The change in blood lipid levels is related to the expression of LPL, which is enhanced by HDAC11-AS1 through regulating adropin histone deacetylation in vitro and in vivo. In conclusion, HDAC11-AS1 plays an anti-atherogenic role through adropin to induce LPL expressions, thereby enhancing TG metabolism. The results are valuable for the further development of HDAC11-AS1 and its clinical applications. It provides a new clinical therapeutic target for cardiovascular disease treatment.

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Funding

The authors gratefully acknowledge the financial supports from the National Natural Sciences Foundation of China (81800386) and the scientific research project of health commission of Hunan province (202101021784).

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Authors and Affiliations

  1. Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Liang Li

  2. Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Wei Xie

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Liang Li supplied conception, design, execution of the experiments, analysis and interpretation of data, and writing of the initial draft of the manuscript. Wei Xie critically evaluated and edited the manuscript. All authors reviewed the manuscript.

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Correspondence to Wei Xie.

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Li, L., Xie, W. LncRNA HDAC11-AS1 Suppresses Atherosclerosis by Inhibiting HDAC11-Mediated Adropin Histone Deacetylation. J. of Cardiovasc. Trans. Res. 15, 1256–1269 (2022). https://doi.org/10.1007/s12265-022-10248-7

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