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Elevated Serum Bone Morphogenetic Protein 4 in Patients with Chronic Kidney Disease and Coronary Artery Disease

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Abstract

Chronic kidney disease (CKD) is associated with increased coronary artery disease (CAD) and coronary artery calcification. We hypothesized that the osteogenic factor, bone morphogenetic protein-4 (sBMP-4), is elevated in subjects with both CKD and CAD. Serum was collected from 79 subjects undergoing diagnostic angiography and stratified according to CAD and CKD status. Subjects with both CAD and CKD had significantly elevated sBMP-4 compared to those with only one or no disease. sBMP-4 continued to be associated with the presence of both diseases after adjustment for other risk factors. To determine if sBMP-4 is associated with coronary artery calcification, we compared coronary artery calcium scores (CAC) to sBMP-4 in 22 subjects. A positive correlation between CAC and sBMP-4 was seen. In conclusion, sBMP-4 is elevated in patients with both CAD and CKD and positively correlates with CAC, suggesting a role for sBMP-4 in the increased CAD seen in CKD patients.

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Acknowledgments

This project was supported by grants from the National Center for Research Resources (5 P20 RR018766-10) and the National Institute of General Medical Sciences (8 P20 GM103514-10) from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA

    Paul F. Stahls III & Corey K. Goldman

  2. Laboratory of Molecular Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA

    Daniel J. Lightell Jr, Stephanie C. Moss & T. Cooper Woods

  3. Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center—New Orleans, New Orleans, LA, USA

    T. Cooper Woods

  4. Laboratory of Molecular Cardiology, Institute for Translational Research, Ochsner Clinic Foundation, Biomedical Research Building, 1N412, 1514 Jefferson Highway, New Orleans, LA, 70121, USA

    T. Cooper Woods

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  1. Paul F. Stahls III
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  2. Daniel J. Lightell Jr
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  3. Stephanie C. Moss
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  5. T. Cooper Woods
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Correspondence to T. Cooper Woods.

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Stahls, P.F., Lightell, D.J., Moss, S.C. et al. Elevated Serum Bone Morphogenetic Protein 4 in Patients with Chronic Kidney Disease and Coronary Artery Disease. J. of Cardiovasc. Trans. Res. 6, 232–238 (2013). https://doi.org/10.1007/s12265-012-9429-9

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  • DOI: https://doi.org/10.1007/s12265-012-9429-9

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