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A Systematic Characterization of Structural Brain Changes in Schizophrenia

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Abstract

A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia, such as voxel-based morphometry (VBM), tensor-based morphometry (TBM), and projection-based thickness (PBT), is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of schizophrenia. However, such studies are still lacking. Here, we performed VBM, TBM, and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy controls. We found that, although all methods detected wide-spread structural changes, different methods captured different information – only 10.35% of the grey matter changes in cortex were detected by all three methods, and VBM only detected 11.36% of the white matter changes detected by TBM. Further, pattern classification between patients and controls revealed that combining different measures improved the classification accuracy (81.9%), indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (2017YFC0909201 and 2018YFC1314300), the National Natural Science Foundation of China (81571659, 81971694, 81971599, 81771818, 81425013, and 81871052), and the Tianjin Key Technology R&D Program (17ZXMFSY00090).

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    1. School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China

      Wasana Ediri Arachchi, Yanmin Peng, Xi Zhang, Chunshui Yu & Meng Liang

    2. Department of Radiography and Radiotherapy, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Ratmalana, 10390, Sri Lanka

      Wasana Ediri Arachchi

    3. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China

      Wen Qin, Chuanjun Zhuo & Chunshui Yu

    4. Department of Psychiatric-Neuroimaging-Genetics and Comorbidity Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin, 300222, China

      Chuanjun Zhuo

    5. CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China

      Chunshui Yu

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    Ediri Arachchi, W., Peng, Y., Zhang, X. et al. A Systematic Characterization of Structural Brain Changes in Schizophrenia. Neurosci. Bull. 36, 1107–1122 (2020). https://doi.org/10.1007/s12264-020-00520-8

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