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Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease Among Han Chinese

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Abstract

In this study, the distribution of five Alzheimer’s disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4.482, P = 0.004), the RS2305421 GG genotype (adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype (adjusted OR = 2.375, P = 0.028) were associated with a higher score on the ABC (Aβ plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD, the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research.

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Acknowledgements

We would like to extend our appreciation to Ms. Yunli Ling for preparing the mounted paraffin sections. This work was supported by grants from the National Natural Science Foundation of China (81271239, 81771205, and 91632113), the Institute of Basic Medical Sciences/Chinese Academy of Medical Sciences (CAMS) Dean’s Fund (2011RC01), the CAMS Innovation Fund for Medical Sciences (2016-I2M-1004), and the Natural Science Foundation and Major Basic Research Program of Shanghai Municipality, China (16JC1420500 and 16JC1420502).

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Authors and Affiliations

  1. Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China

    Qian Yang, Qing Zhang, Pan Liu, Tianyi Sun, Xiaojing Qian, Wenying Qiu & Chao Ma

  2. Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing, 100005, China

    Qian Yang, Kang Chen, Hanlin Zhang, Changlin Gong, Qing Zhang, Pan Liu & Tianyi Sun

  3. Eight-Year MD Program, Peking Union Medical College, Beijing, 100730, China

    Kang Chen, Hanlin Zhang & Changlin Gong

  4. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA

    Wanying Zhang

  5. National Experimental Teaching Demonstration Center of Basic Medicine, Peking Union Medical College, Beijing, 100005, China

    Yuanyuan Xu

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  1. Qian Yang
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Yang, Q., Chen, K., Zhang, H. et al. Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease Among Han Chinese. Neurosci. Bull. 35, 193–204 (2019). https://doi.org/10.1007/s12264-019-00343-2

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