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Intervention Effect of Repetitive TMS on Behavioral Adjustment After Error Commission in Long-Term Methamphetamine Addicts: Evidence From a Two-Choice Oddball Task

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Abstract

Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless, few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine (METH) dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC). Twenty-nine male long-term METH addicts (for > 3 years) were randomly assigned to high-frequency (10 Hz, n = 15) or sham (n = 14) rTMS of the left DLPFC during a two-choice oddball task. Twenty-six age-matched, healthy male adults participated in the two-choice oddball task pretest to establish normal performance for comparison. The results showed that 10 Hz rTMS over the left DLPFC significantly decreased the post-error slowing effect in response times of METH addicts. In addition, the 10 Hz rTMS intervention remarkably reduced the reaction times during post-error trials but not post-correct trials. While the 10 Hz rTMS group showed a more pronounced post-error slowing effect than the healthy participants during the pretest, the post-error slowing effect in the posttest of this sample was similar to that in the healthy participants. These results suggest that high-frequency rTMS over the left DLPFC is a useful protocol for the improvement of behavioral adjustment after error commission in long-term METH addicts.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (31371042, 31400906 and 31600886), and the Key Program of the Higher Education Institutions of Henan Province, China (17AJ90002).

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Authors and Affiliations

  1. Key Laboratory of Cognition and Personality of the Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, 400715, China

    Qiongdan Liang, Jiemin Yang, Xiang Li & Jiajin Yuan

  2. Da Lian Shan Institute of Addiction Rehabilitation, Nanjing, China

    Jia Lin

  3. Nanjing Technical University, Nanjing, China

    Yijiang Chen

  4. School of Education, Nanyang Normal University, Nanyang, China

    Xianxin Meng

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Liang, Q., Lin, J., Yang, J. et al. Intervention Effect of Repetitive TMS on Behavioral Adjustment After Error Commission in Long-Term Methamphetamine Addicts: Evidence From a Two-Choice Oddball Task. Neurosci. Bull. 34, 449–456 (2018). https://doi.org/10.1007/s12264-018-0205-y

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