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Prefrontal cortex and sensory cortices during working memory: quantity and quality

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Abstract

The activity in sensory cortices and the prefrontal cortex (PFC) throughout the delay interval of working memory (WM) tasks reflect two aspects of WM—quality and quantity, respectively. The delay activity in sensory cortices is fine-tuned to sensory information and forms the neural basis of the precision of WM storage, while the delay activity in the PFC appears to represent behavioral goals and filters out irrelevant distractions, forming the neural basis of the quantity of task-relevant information in WM. The PFC and sensory cortices interact through different frequency bands of neuronal oscillation (theta, alpha, and gamma) to fulfill goal-directed behaviors.

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Authors and Affiliations

  1. Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China

    Yixuan Ku

  2. MIND Research Institute, Irvine, California, USA

    Mark Bodner

  3. Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA

    Yong-Di Zhou

  4. NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, 200122, China

    Yong-Di Zhou

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  1. Yixuan Ku
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Correspondence to Yixuan Ku.

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Ku, Y., Bodner, M. & Zhou, YD. Prefrontal cortex and sensory cortices during working memory: quantity and quality. Neurosci. Bull. 31, 175–182 (2015). https://doi.org/10.1007/s12264-014-1503-7

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