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Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patients with Curative Gastrectomy

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Pathology & Oncology Research

Abstract

Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer with relatively low incidence. This article was designed to demonstrate that the total tumor volume (TTV) should be treated as an important prognostic factor in SMGC patients with curative gastrectomy. This study retrospective analyzed 140 SMGC patients who received curative gastrectomy between December 2004 and December 2014 in our hospital. Clinicopathological features, preoperative evaluation, surgical treatment, and outcome parameters were reviewed and analyzed. This study applied univariate and multivariate analyses to identify the most significant prognostic factors. In the univariate analysis, the TTV, pTTVNM, pN stage, pT of main tumor were all significant prognostic factors in SMGC patients (all P < 0.05). In the multivariate analysis, pN stage, TTV and pTTVNM were confirmed to be independent prognostic factors (all P < 0.05). In the comparison of survival analysis, the pTTVNM stage system (P < 0.05) was superior to the pTNM stage system (P > 0.05) in SMGC patients. In conclusion, the TTV should be considered as an independent prognostic factor in overall survival in SMGC patients who received curative gastrectomy. The pTTVNM stage should be recommended as a suitable staging system for SMGC patients.

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Abbreviations

SMGC:

Synchronous multiple gastric cancer

TTV:

Total tumor volume

GC:

Gastric cancer

AJCC:

American Joint Committee on Cancer

UICC:

Union of International Cancer Control

TNM:

Tumor-node-metastasis

TV:

Tumor volume

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Acknowledgments

This study was supported by grants from the Key Research and Development Foundation of Shandong Province [NO. 2017GSF218034] and the Science Foundation of Qilu Hospital of Shandong University [NO. 2017QLQN16]. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing of this manuscript.

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Authors and Affiliations

  1. Department of General Surgery, Qilu Hospital of Shandong University, No.107, West of Wenhua Street, Lixia District, 250012, Jinan, China

    Xiaolong Tang, Qingsi He, Guorui Sun & Hui Qu

  2. Department of Health Management Center, Qilu Hospital of Shandong University, 250012, Jinan, China

    Jia Liu

  3. Qilu Medical College of Shandong University, 250011, Jinan, Shandong, China

    Lei Gao, Jingbo Shi, Jianhong Ye & Yahang Liang

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  1. Xiaolong Tang
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  2. Qingsi He
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Correspondence to Guorui Sun.

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Tang, X., He, Q., Sun, G. et al. Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patients with Curative Gastrectomy. Pathol. Oncol. Res. 26, 2169–2175 (2020). https://doi.org/10.1007/s12253-020-00804-4

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  • DOI: https://doi.org/10.1007/s12253-020-00804-4

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