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Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer

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Pathology & Oncology Research

Abstract

We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression TUBA4B in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.

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Acknowledgments

Funding/Grant Support/Acknowledgments: This study was financially supported by the National Natural Science Foundation of China (8140736), the Zhejiang Provincial Natural Science Foundation (LQ16H160020), and the Wenzhou Municipal Science and Technology Bureau, China (Y20150097).

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Authors and Affiliations

  1. Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People’s Republic of China

    Jian Chen, Lijuan Hu, Junjun Wang, Fan Zhang, Gang Xu, Yumin Wang & Qinshi Pan

  2. Department of Intensive Care Unit, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People’s Republic of China

    Jie Chen

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  1. Jian Chen
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  2. Lijuan Hu
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  3. Junjun Wang
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  4. Fan Zhang
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  5. Jie Chen
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  6. Gang Xu
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  7. Yumin Wang
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  8. Qinshi Pan
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Corresponding authors

Correspondence to Yumin Wang or Qinshi Pan.

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Conflict of Interest Statement

These conflicts did not interfere with the conduct of this study. All other authors have no other conflict of interest to declare.

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Jian Chen and Lijuan Hu contributed equally to this work

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Chen, J., Hu, L., Wang, J. et al. Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer. Pathol. Oncol. Res. 23, 265–270 (2017). https://doi.org/10.1007/s12253-016-0089-y

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  • DOI: https://doi.org/10.1007/s12253-016-0089-y

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