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A critical Analysis of the Relationship Between Aldehyde dehydrogenases-2 Glu487Lys Polymorphism and Colorectal Cancer Susceptibility

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Pathology & Oncology Research

Abstract

Studies investigating the association between genetic polymorphism of aldehyde dehydrogenases-2 (ALDH-2) Glu487Lys and colorectal cancer (CRC) risk have reported conflicting results. Given this uncertainty, we carried out a critical analysis of published case-control studies to derive a more precise estimation of this relationship. Published literature from PubMed, EMBASE and China Knowledge Resource Integrated Database were retrieved, and the literature search was updated in June 2014. Eleven studies comprising 6965 subjects were selected (2300 cases and 4665 controls). Overall, our study showed no statistical significance for CRC risk associated with any of the genetic models of ALDH-2 Glu487Lys polymorphism. When studies were stratified for control source, a decreased risk of CRC for participants with Lys/Lys was observed in population based case-control studies [Lys/Lys vs. (Glu/Lys + Glu/Glu): odds ratio (OR) = 0.57, 95% confidence interval (CI) = 0.38–0.87]. Furthermore, we also confirmed the significant correlation between Glu487Lys polymorphism and the influence on the risk of rectal cancer in males [Glu/Glu vs. (Glu/Lys + Lys/Lys): OR = 1.52, 95%CI = 1.10–2.08]. The combined effects of the two gene polymorphisms [ALDH-2 and alcohol dehydrogenase 1B (ADH-1B)] were also studied. Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57–20.38). Similar trends were observed for the other two types of comparisons. Our study supports that ALDH-2 Glu487Lys polymorphism is associated with significant reduced risks of CRC in population-based samples, and of rectal cancer in males.

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Conflict of Interest

The Authors declare that there is no conflict of interest.

Authors’ Contribution

BC, KWH carried out the literature search, and draft the manuscript. JWZ and ZJW performed the statistical analysis. MMX, XLM conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript. MMX accepts full responsibility for the work and has accessed to the data, and overseen the decision to publish.

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  1. Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China

    Bo Chen, Kong-Wang Hu, Jia-Wei Zhang, Zhi-Jian Wei, Xiang-Ling Meng & Mao-Ming Xiong

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  1. Bo Chen
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Correspondence to Mao-Ming Xiong.

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Chen, B., Hu, KW., Zhang, JW. et al. A critical Analysis of the Relationship Between Aldehyde dehydrogenases-2 Glu487Lys Polymorphism and Colorectal Cancer Susceptibility. Pathol. Oncol. Res. 21, 727–733 (2015). https://doi.org/10.1007/s12253-014-9881-8

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