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Gammaaminobutyric Acid A Receptor Alpha 3 Subunit is Overexpressed in Lung Cancer

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  • Published:
Pathology & Oncology Research

Abstract

The identification of tumor-associated antigens, which are specifically expressed in cancer tissues, is very important for immunotherapy of lung cancer. We have combined the in silico screening and experimental verifying to identify genes that are differently expressed in cancers compared with their corresponding normal tissues. Using these methods, we have identified that GABRA3 gene was overexpressed in lung cancer and rarely expressed in other cancers. Furthermore, GABRA3 protein expression was significantly higher in the lower grade of lung cancer. It may compose functional GABA-gated channel with other subunits. This study demonstrated GABRA3 could be a potential biomarker for diagnosis of lung cancer, and GABAA receptors may play an important role in cancer differentiation.

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Authors and Affiliations

  1. Tumor Immunobiology Laboratory of Cancer Research Institute, Central South University, Changsha, Hunan Province, 410078, China

    Yan Liu, Fengjie Guo, Yongqing Tong, Jian Huang, Jinyue Hu & Guancheng Li

  2. Affiliated Hospital of Weifang School of Medicine, Weifang, Shandong Province, 261031, China

    Miao Dai

  3. The Fist Hospital of Changsha, Changsha, Hunan Province, 410078, China

    Di Wang

Authors
  1. Yan Liu
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  2. Fengjie Guo
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  3. Miao Dai
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  4. Di Wang
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  5. Yongqing Tong
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  6. Jian Huang
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  7. Jinyue Hu
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  8. Guancheng Li
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Correspondence to Guancheng Li.

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Liu, Y., Guo, F., Dai, M. et al. Gammaaminobutyric Acid A Receptor Alpha 3 Subunit is Overexpressed in Lung Cancer. Pathol. Oncol. Res. 15, 351–358 (2009). https://doi.org/10.1007/s12253-008-9128-7

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  • DOI: https://doi.org/10.1007/s12253-008-9128-7

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