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Detection of Deregulated Pathways to Lymphatic Metastasis in Oral Squamous Cell Carcinoma

  • Original Paper
  • Published:
Pathology & Oncology Research

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignancy, in which lymph node metastasis is a major determinant of outcome. The pathway deregulation resulting from a large number of somatic genetic alterations in the development of the tumor, plays an important role in lymphatic metastasis process. To detect the deregulated pathways to lymphatic metastasis in OSCC, we performed pathway-oriented analysis using gene expression profile from 16 samples without lymphatic metastasis and 27 samples with lymphatic metastasis. We identified seven significantly (p < 0.05) deregulated pathways: the erythropoietin (EPO) Signaling Pathway, Signaling Pathway from G-Protein Families, Cytokine–cytokine receptor interaction, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, Ribosome, Colorectal cancer, B cell receptor signaling pathway. The biological relevance of these pathways to OSCC is the focus of ongoing studies, as well as complex interactions and crosstalk between them. These pathways might provide additional clues about factors that regulate the course for OSCC patients and might offer new opportunities for therapeutic intervention.

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Abbreviations

cAMP:

cyclic AMP

EPO:

erythropoietin

EPOR:

erythropoietin receptor

GPCRs:

G-protein-coupled receptors

HNSCC:

squamous cell carcinomas of the head and neck

JAK:

Janus kinase

MAP kinase:

mitogen-activated protein kinase

NSCLC:

non-small cell lung carcinoma

OSCC:

Oral squamous cell carcinoma

STAT:

signal transducer and activator of transcription

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Acknowledgment

This work was supported in part by the Natural Science Foundation of Heilongjiang Province (Grant Nos. D00-15, ZJG0501, GB03C602-4 and F2004-02), National Natural Science Foundation of China (Grant Nos. 60601010,30170515, 30370798, 30571034 and 30570424), the Heilongjiang Province Department of Education Outstanding Overseas Scientist grant (Grant No. 1055HG009), Natural Science Foundation of Beijing City (Grant No. KM200610025011) and Health Department of Heilongjiang Province Key Project (2005-39), the Innovative Fund of Harbin Medical University Graduate Student (Grant No.HCXS2007001).

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Authors and Affiliations

  1. The Stomatological College, and Department of Bioinformatics, Harbin Medical University, Harbin, China

    Eryang Zhao, Jiankai Xu, Xiaodong Yin, Yu Sun, Jinna Shi & Xia Li

  2. The Biomedical Engineering Institute, Capital Medical University, Beijing, China

    Xia Li

  3. Department of Bioinformatics, Harbin Medical University, Harbin, 150081, China

    Xia Li

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  1. Eryang Zhao
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  2. Jiankai Xu
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  3. Xiaodong Yin
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  4. Yu Sun
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  5. Jinna Shi
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  6. Xia Li
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Corresponding author

Correspondence to Xia Li.

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Eryang Zhao, Jiankai Xu, Xiaodong Yin contributed equally.

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Zhao, E., Xu, J., Yin, X. et al. Detection of Deregulated Pathways to Lymphatic Metastasis in Oral Squamous Cell Carcinoma. Pathol. Oncol. Res. 15, 217–223 (2009). https://doi.org/10.1007/s12253-008-9102-4

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  • DOI: https://doi.org/10.1007/s12253-008-9102-4

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