Skip to main content

Advertisement

SpringerLink
Log in

The Potential of Digital Microscopy in Breast Pathology

  • Brief Communication
  • Published:
Pathology & Oncology Research

Abstract

The rapidly evolving field of digital microscopy supports the efficient exploitation of inherent information from stained glass slides to offer widespread utilization in breast histopathology. Digital image signals can be accurately measured, integrated into databases and shared through computer networks. Therefore, digital microscopy can boost telepathology-consultation, gradual- and postgradual teaching, proficiency testing, intra- and interlaboratory validation of biomarker screening interpretation, and automated image analysis of biomarker expression for both diagnostics and research applications. This is a brief highlight of the potential of digital microscopy in breast pathology applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Anderson WF, Luo S, Chatterjee N, Rosenberg PS, Matsuno RK, Goodman MT, Hernandez BY, Reichman M, Dolled-Filhart MP, O’Regan RM, Garcia-Closas M, Perou CM, Jatoi I, Cartun RW, Sherman ME (2008) Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program. Breast Cancer Res Treat, Feb 7. doi:10.1007/s10549-008-9918-3

  2. Bloom K, Harrington D (2004) Enhanced Accuracy of HER-2/neu immunohistochemical scoring using digital microscopy. Am J Clin Pathol 121:619–630

    Article  Google Scholar 

  3. Borgen E, Naume B, Nesland JM, Nowels KW, Pavlak N, Ravkin I, Goldbard S (2001) Use of automated microscopy for the detection of disseminated tumor cells in bone marrow samples. Cytometry 46:215–221

    Article  PubMed  CAS  Google Scholar 

  4. Cserneky M, Szende B, Fonyad L, Krenacst T (2008) Telepathology in Hungary. In: Kumar S (ed) Telepathology. Springer, Berlin (in press)

  5. Drev P, Grazio SF, Bračko M (2008) Tissue microarrays for routine diagnostic assessment of HER-2 status in breast carcinoma. Appl Immunohistochem Mol Morphol 16:179–184 Jan 25 [Epub ahead of print]

    Article  PubMed  CAS  Google Scholar 

  6. Kayser K, Molnar B, Weinstein RS (2006) Virtual slides technology. In: Virtual microscopy: fundamentals, applications, perspectives of electronic tissue-based diagnosis. VSV, Berlin, pp 103–123

    Google Scholar 

  7. Krenacs T, Ficsor L, Varga VS, Angeli V, Molnar B (2008) Digital microscopy for boosting database integration and analysis in TMA studies. In: Simon R (ed) Methods in molecular biology. Humana, Totowa, NJ (in press)

  8. Kumar RK, Velan GM, Korell SO, Kandara M, Dee FR, Wakefield D (2004) Virtual microscopy for learning and assessment in pathology. J Pathol 204:613–618

    Article  PubMed  Google Scholar 

  9. Lundin M, Lundin J, Helin H, Isola J (2004) A digital atlas of breast histopathology: an application of web based virtual microscopy. J Clin Pathol 57:1288–1291

    Article  PubMed  CAS  Google Scholar 

  10. Schrader T, Hufnagl P, Schlake W, Dietel M (2005) Study of efficiency of teleconsultation: the Telepathology Consultation Service of the Professional Assoziation of German Pathologists for the screening program of breast carcinoma (in German). Verh Dtsch Ges Pathol 89:211–218

    PubMed  CAS  Google Scholar 

  11. Skaland I, Ovestad I, Janssen EA, Klos J, Kjellevold KH, Helliesen T, Baak JP (2008) Digital image analysis improves the quality of subjective HER-2 expression scoring in breast cancer. Appl Immunohistochem Mol Morphol 16(2):185–190

    Article  PubMed  CAS  Google Scholar 

  12. Teodorovic I, Isabelle M, Carbone A, Passioukov A, Lejeune S, Jaminé D, Therasse P, Gloghini A, Dinjens WN, Lam KH, Oomen MH, Spatz A, Ratcliffe C, Knox K, Mager R, Kerr D, Pezzella F, van Damme B, van de Vijver M, van Boven H, Morente MM, Alonso S, Kerjaschki D, Pammer J, Lopez-Guerrero JA, Llombart Bosch A, van Veen EB, Oosterhuis JW, Riegman PH (2006) TuBaFrost 6: virtual microscopy in virtual tumour banking. Eur J Cancer. 42:3110–3116

    Article  PubMed  CAS  Google Scholar 

  13. Witzig TE, Bossy B, Kimlinger T, Roche PC, Ingle JN, Grant C, Donohue J, Suman VJ, Harrington D, Torre-Bueno J, Bauer KD (2002) Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy. Clin Cancer Res 8:1085–1091

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, 1085, Budapest, Hungary

    T. Krenacs, I. Zsakovics & Cs. Diczhazi

  2. 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

    L. Ficsor, V. S. Varga & B. Molnar

Authors
  1. T. Krenacs
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Zsakovics
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cs. Diczhazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Ficsor
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. S. Varga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Molnar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Krenacs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krenacs, T., Zsakovics, I., Diczhazi, C. et al. The Potential of Digital Microscopy in Breast Pathology. Pathol. Oncol. Res. 15, 55–58 (2009). https://doi.org/10.1007/s12253-008-9087-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-008-9087-z

Keywords

Search

Navigation