Abstract
Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm typically arising in the pleura and involving the orbit as its most common extra-pleural location. We herein describe a well documented case of orbital SFT arising in a 62-year-old woman presenting with progressive swelling of the right upper eyelid and proptosis. The tumor had a benign clinical course, with radical surgical excision followed by regression of the clinical symptoms. We review the clinical, histopathological, and immunohistochemical features of the orbital SFT described so far, with particular emphasis on differential diagnosis with other spindle cell orbital neoplasms.
References
De Saint Aubain Somerhausen N, Rubin BP, Fletcher CDM (1999) Mixoid solitary fibrous tumor: a study of seven cases with emphasis on differential diagnosis. Mod Pathol 12:463–471
Klemper C, Rabin CB (1931) Primary neoplasm of the pleura; a report of five cases. Arch Pathol 11:385–412
El-Naggar AK, Ro JY, Ayala AG et al (1989) Localized fibrous tumor of the serosal cavities. Am J Clin Pathol 13:199–209
Kottke-Marchant K, Hart WR, Broughan T (1989) Localized fibrous tumor (localized fibrous mesothelioma) of the liver. Cancer 64:1096–1102
Witkin GB, Rosai J (1989) Solitary fibrous tumor of the mediastinum. Am J Surg Pathol 13:547–557
Witkin GB, Rosai J (1991) Solitary fibrous tumor of the upper respiratory tract. Am J Surg Pathol 15:842–848
Fukunaga M, Nikaido T (1997) Solitary fibrous tumor of the renal peri-pelvis. Histopathology 30:451–456
Prevot S, Penna C, Imbert JC et al (1996) Solitary fibrous tumor of the adrenal gland. Mod Pathol 9:1170–1174
Fisher C, Bisceglia M (1994) Solitary fibrous tumor of the spermatic cord. Br J Urol 74:798–789
Hasegawa T, Hirose T, Seki K et al (1996) Solitary fibrous tumor of the soft tissue. Am J Clin Pathol 106:325–331
Cowper SE, Kilpatrick T, Proper S et al (1999) Solitary fibrous tumor of the skin. Am J Dermatopathol 21(3):213–219
Zuckerberg ML, Rosemberg AE, Randolph G et al (1991) Solitary fibrous tumor of the nasal cavity and paranasal sinuses. Am J Surg Pathol 15:126–130
England DM, Hochholzer L, McCarthy MJ (1989) Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 13:640–658
Chan JKC (1997) Solitary fibrous tumor—everywhere and a diagnosis in vogue. Histopathology 31:568–576
Frederick A Font J, Font RL (1986) Orbit. In: Spencer WH (ed) Ophthalmic pathology: an atlas and textbook, 3rd edn. Saunders, Philadelphia, pp 2459–2860
Festa S, Lee HJ, Langer P et al (1999) Solitary fibrous tumor of the orbit: CT and pathologic correlation. Neuroradiology 41:52–54
Scott IU, Tanenbaum M, Rubin D et al (1996) Solitary fibrous tumor of the lacrimal gland fossa. Ophthalmology 103:1613–1618
Woo KI, Suh YL, Kim YD (1999) Solitary fibrous tumor of the lacrimal sac. Ophthal Plast Reconstr Surg 15(6):450–453
Polito E, Tosi M, Toti P et al (2002) Orbital solitary fibrous tumor with aggressive behaviourThree cases and review of the literature. Graefes Arch Clin Exp Ophthalmol 240(7):570–574
Hayashi S, Kurihara H, Hirato J et al (2001) Solitary fibrous tumor of the orbit with an extraorbital extension: case report. Neurosurgery 49(5):1241–1245
Carrera M, Prat J, Quintana M (2001) Malignant solitary fibrous tumor of the orbit: report of a case with 8 years follow-up. Eye 15:102–104
Vallat-Decouvelaere AV, Dry SM, Fletcher CDM (1998) Atypical and malignant solitary fibrous tumors in extra-thoracic locations. Evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22:1501–1511
Hasegawa T, Matsuno Y, Shimoda T et al (1999) Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behaviour. Hum Pathol 30:1464–1473
Enzinger FM, Weiss SW (1997) Soft tissue tumors, 4th edn. Mosby, USA
Moran CA, Suster S, Koss MN (1992) The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura. Sem Diagn Pathol 9:169–180
Nielsen GP, O’Connell JX, Dickersin GR et al (1997) Solitary fibrous tumor of soft tissue. A report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical, and ultrastructural data. Mod Pathol 10:1028–1037
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Leoncini, G., Maio, V., Puccioni, M. et al. Orbital Solitary Fibrous Tumor: A Case Report and Review of the Literature. Pathol. Oncol. Res. 14, 213–217 (2008). https://doi.org/10.1007/s12253-008-9055-7
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DOI: https://doi.org/10.1007/s12253-008-9055-7