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Surface modification of silk fibroin nanofibrous mat with dextran for wound dressing

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Abstract

In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM.

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Correspondence to Ki Hoon Lee.

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Kim, M.K., Kwak, H.W., Kim, H.H. et al. Surface modification of silk fibroin nanofibrous mat with dextran for wound dressing. Fibers Polym 15, 1137–1145 (2014). https://doi.org/10.1007/s12221-014-1137-2

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  • DOI: https://doi.org/10.1007/s12221-014-1137-2

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