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Dosimetric evaluation with knowledge-based planning created at different periods in volumetric-modulated arc therapy for prostate cancer: a multi-institution study

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Abstract

Dosimetric evaluation and variation assessment were performed with two knowledge-based planning (KBP) models created at different periods for volumetric-modulated arc therapy (VMAT) for prostate cancer at five institutes. The first and second models (F- and S-models) for KBP were created before April 2017 and April 2019, respectively. The S-model was created using feedback plans from the F-model. Dose evaluation was compared between the two models using the same two computed tomography (CT) datasets and structures. The evaluation metrics were the dose received by 95.0% and 2.0% of the planning target volume (PTV); dose–volume parameters to the rectum and bladder as V90, V80, and V50; and monitor unit (MU). Dosimetric variation was compared by exporting estimated dose–volume histograms for each model to the Model Analytics website and assessing the organ at risk volume. There were no dosimetric differences between the two models for PTV. The V50 of the rectum in the S-model had improved compared to that of the F-model (case I: 49.3 ± 15.6 and 43.5 ± 15.2 [p = 0.08]; case II: 42.5 ± 16.9 and 36.0 ± 15.6 [p = 0.138]). The differences in other parameters were within ± 1.8% between the rectum and the bladder. The MU was slightly higher in the S-model than in the F-model, and dosimetric variation was reduced to the rectum and bladder among all the institutes. The polished S-model for KBP could be used for standardization of the plan quality and sharing of KBP models in VMAT for prostate cancer.

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Funding

This study was funded by a Japanese Society of Radiological Technology (JSRT) Research Grant (2019, 2020). This work was supported partly by the Japan Society for the Promotion of Science (JSPS) KAKENHI grant number 17K15817.

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Authors and Affiliations

  1. Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan

    Hajime Monzen, Mikoto Tamura & Kazuki Kubo

  2. Department of Radiation Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 537-8567, Japan

    Yoshihiro Ueda

  3. Divisin of Radiology, Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Jun-ichi Fukunaga

  4. Department of Radiation Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Tatsuya Kamima

  5. Department of Radiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, Shizuoka, 430-8558, Japan

    Yuta Muraki

  6. Department of Radiation Oncology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan

    Kiyoshi Nakamatsu

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  1. Hajime Monzen
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  2. Mikoto Tamura
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  7. Kazuki Kubo
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  8. Kiyoshi Nakamatsu
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Correspondence to Hajime Monzen.

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Kindai University review board No. 31-273.

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Monzen, H., Tamura, M., Ueda, Y. et al. Dosimetric evaluation with knowledge-based planning created at different periods in volumetric-modulated arc therapy for prostate cancer: a multi-institution study. Radiol Phys Technol 13, 327–335 (2020). https://doi.org/10.1007/s12194-020-00585-0

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  • DOI: https://doi.org/10.1007/s12194-020-00585-0

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